The metabolic syndrome and antioxidant concentrations - Findings from the Third National Health and Nutrition Examination Survey
The metabolic syndrome and antioxidant concentrations - Findings from the Third National Health and Nutrition Examination Survey
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DOI：
10.2337/diabetes.52.9.2346
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发表时间：
2003-09-01
期刊：
影响因子：
7.7
通讯作者：
Brown, DW
中科院分区：
文献类型：
--
作者：
Ford, ES;Mokdad, AH;Brown, DW
氧化应激可能在糖尿病和心血管疾病的病理生理学中发挥作用，但对代谢综合征患者中的抗氧化状态知之甚少，这些患者具有发展这些疾病的高风险。利用第三次全国健康与营养调查（1988 - 1994）的数据，我们比较了8,808名年龄大于或等于20岁的美国成年人中维生素A、C和E、视黄酯、五种类胡萝卜素和硒的循环浓度，这些人有或没有代谢综合征。在调整年龄，性别，种族或民族，教育，吸烟状况，可替宁浓度，体育活动，水果和蔬菜摄入量以及维生素或矿物质使用后，代谢综合征参与者的视黄酯，维生素C和类胡萝卜素浓度显着降低，番茄红素除外。通过对血脂浓度的额外调整，患有代谢综合征的参与者的维生素E浓度显着低于没有综合征的参与者。两组间视黄醇浓度相似。在排除糖尿病参与者后，结果非常相似。代谢综合征患者的水果和蔬菜摄入量也较低。患有代谢综合征的成年人有几种抗氧化剂的次优浓度，这可能部分解释了他们患糖尿病和心血管疾病的风险增加。
Oxidative stress may play a role in the pathophysiology of diabetes and cardiovascular disease, but little is known about antioxidant status among individuals with the metabolic syndrome who are at high risk for developing these conditions. Using data from the Third National Health and Nutrition Examination Survey (1988 - 1994), we compared circulating concentrations of vitamins A, C, and E; retinyl esters; five carotenoids; and selenium in 8,808 U.S. adults aged greater than or equal to20 years with and without the metabolic syndrome. After adjusting for age, sex, race or ethnicity, education, smoking status, cotinine concentration, physical activity, fruit and vegetable intake, and vitamin or mineral use, participants with the metabolic syndrome had significantly lower concentrations of retinyl esters, vitamin C, and carotenoids, except lycopene. With additional adjustment for serum lipid concentrations, vitamin E concentrations were significantly lower in participants with the metabolic syndrome than those without the syndrome. Retinol concentrations were similar between the two groups. After excluding participants with diabetes, the results were very similar. Consumption of fruits and vegetables was also lower among people with the metabolic syndrome. Adults with the metabolic syndrome have suboptimal concentrations of several antioxidants, which may partially explain their increased risk for diabetes and cardiovascular disease.