Detecting esophageal disease with second-generation capsule endoscopy: initial evaluation of the PillCam ESO 2
Detecting esophageal disease with second-generation capsule endoscopy: initial evaluation of the PillCam ESO 2
复制标题
DOI：
10.1055/s-2007-995645
复制
发表时间：
2008-04-01
期刊：
影响因子：
9.3
通讯作者：
Elialkim, R.
中科院分区：
文献类型：
--
作者：
Gralnek, I. M.;Adler, S. N.;Elialkim, R.
背景和研究目的：食管胶囊内镜（ECE）为评估食管提供了一种替代的微创方式。本研究评价了第二代食管胶囊内窥镜PiIlCam ESO 2的性能和测试特性。方法：纳入已知或疑似食管疾病的成人。使用简化的摄入程序，每例患者均使用PillCam ESO 2进行胶囊式内窥镜检查。ECE后，由对ECE结果不知情的研究者在同一天进行食管胃内窥镜检查（EGD）。以随机顺序，胶囊内窥镜录像阅读和解释的研究调查员不知情EGD result.Results：28例患者（19名男性，9名女性;平均年龄53.3岁）。在82%的患者中，PillCam ESO 2至少显示了75%的Z线。每处病变分析表明，PillCam ESO 2在30/43处病变（69.8%）中获得明确结果，EGD在29/43处病变（67.4%）中获得明确结果，P值=0.41。与EGD检测疑似Barrett食管和食管炎相比，PillCam ESO 2的灵敏度为100%，特异性为74%，灵敏度为80%，特异性为87%。PillCam ESO 2在描述Z线时与EGD的一致率为86%（kappa统计量0.68）。改良的摄入方案提供了出色的清洁效果，86%的病例中，气泡/唾液对Z线图像没有影响或影响很小。结论：PillCam ESO 2显示了出色的Z线可视化。与标准EGD相比，PillCam ESO 2具有良好的测试特性，疑似Barrett食管和食管炎的检出率较高。这项研究提供了间接验证的简化摄入程序。PillCam ESO 2可获得高质量的食管图像，性能安全，应能够替代当前的PillCam ESO。
Background and study aim: Esophageal capsule encloscopy (ECE) provides an alternative, minimally invasive modality for evaluating the esophagus. This study evaluates the performance and test characteristics of a second-generation esophageal capsule encloscope, the PiIlCam ESO 2.Methods: Adults with known or suspected esophageal disease were included. Using the simplified ingestion procedure, each patient underwent capsule endoscopy with the PillCam ESO 2. Following ECE, esophagogastroduodenoscopy (EGD) was performed on the same day by an investigator who was blinded to the results of the ECE. In random order, capsule endoscopy videos were read and interpreted by the study investigator blinded to EGD results.Results: 28 patients (19 men, 9 women; mean age 53.3 years) were included. In 82% of the patients, at least 75 % of the Z line was visualized by the PillCam ESO 2. A per-lesion analysis demonstrated that the PillCam ESO 2 had definitive results in 30/43 lesions (69.8%) and EGD in 29/43 (67.4%), P value=0.41. Compared with EGD for detecting suspected Barrett's esophagus and esophagitis, the PillCam ESO 2 had a sensitivity of 100% and a specificity of 74%, and a sensitivity of 80% and a specificity of 87%, respectively. The PillCam ESO 2 demonstrated 86% agreement with EGD in describing the Z line (kappa statistic 0.68). The modified ingestion protocol provided excellent cleansing, with bubbles/saliva having no or only a minor effect on Z line images in 86% of cases.Conclusions: The PillCam ESO 2 demonstrated excellent visualization of the Z line. Compared with standard EGD, the PillCam ESO 2 had good test characteristics with high rates of detection of suspected Barrett's esophagus and esophagitis. This study provides indirect validation of the simplified ingestion procedure. The PillCam ESO 2 acquires high quality esophageal images, performs safely, and should be able to replace the current PillCam ESO.