The intensive care delirium research agenda: a multinational, interprofessional perspective.

The intensive care delirium research agenda: a multinational, interprofessional perspective.
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DOI:
10.1007/s00134-017-4860-7
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发表时间:
2017-09
影响因子:
38.9
通讯作者:
Smith HAB
Smith HAB
中科院分区:
医学1区
文献类型:
--
作者:
Pandharipande PP;Ely EW;Arora RC;Balas MC;Boustani MA;La Calle GH;Cunningham C;Devlin JW;Elefante J;Han JH;MacLullich AM;Maldonado JR;Morandi A;Needham DM;Page VJ;Rose L;Salluh JIF;Sharshar T;Shehabi Y;Skrobik Y;Slooter AJC;Smith HAB

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Delirium, a prevalent organ dysfunctions in critically ill patients, is independently associated with increased morbidity. This last decade has witnessed an exponential growth in delirium research in hospitalized patients, including those critically ill, and this research has highlighted that delirium needs to be better understood mechanistically, to help foster research that will ultimately lead to its prevention and treatment. In this invited, evidence-based paper, a multinational and interprofessional group of clinicians and researchers from within the fields of critical care medicine, psychiatry, pediatrics, anesthesiology, geriatrics, surgery, neurology, nursing, pharmacy and the neurosciences, sought to address five questions: What is the current standard of care in managing ICU delirium? What have been the major recent advances in delirium research and care? What are the common delirium beliefs that have been challenged by recent trials? What are the remaining areas of uncertainty in delirium research? What are some of the top study areas/trials to be done in the next 10 years? Herein, we briefly review the epidemiology of delirium, the current best practices for management of critically ill patients at risk for delirium or experiencing delirium; identify recent advances in our understanding of delirium as well as gaps in knowledge, and discuss research opportunities and barriers to implementation, with the goal of promoting an integrated research agenda.
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