AN ANTIINFLAMMATORY CUM IMMUNOMODULATORY PIPERIDINYLBENZOPYRANONE FROM DYSOXYLUM-BINECTARIFERUM - ISOLATION, STRUCTURE AND TOTAL SYNTHESIS
AN ANTIINFLAMMATORY CUM IMMUNOMODULATORY PIPERIDINYLBENZOPYRANONE FROM DYSOXYLUM-BINECTARIFERUM - ISOLATION, STRUCTURE AND TOTAL SYNTHESIS
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DOI：
10.1016/s0040-4020(01)90352-7
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发表时间：
1988-01-01
期刊：
影响因子：
2.1
通讯作者：
RUPP, RH
中科院分区：
文献类型：
--
作者：
NAIK, RG;KATTIGE, SL;RUPP, RH
(+)-cis-5，7-Dihydroxy-2-methyl-8-[4-(3-hydroxyl-1-methyl)-4H-1-苯并吡喃-4-酮被鉴定为花椒树皮的抗炎及免疫调节活性成分。为其全合成设计的序列也用于合成其(-)-对映体和外消旋体。
(+)-cis-5,7-Dihydroxy-2-methyl-8-[4-(3-hydroxyl-1-methyl) piperidinyl]-4H-1-benzopyran-4-one was identified as the antiinflammatory cum immunomodulatory principle of the stem bark of Dysoxylum binectariferum. The sequence devised for its total synthesis was also used to synthesise its (-)-enantiomer and the racemate.