Acute Myeloid Leukemia Evolving from Myeloproliferative Neoplasms: Many Sides of a Challenging Disease.
Acute Myeloid Leukemia Evolving from Myeloproliferative Neoplasms: Many Sides of a Challenging Disease.
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DOI：
10.3390/jcm10030436
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发表时间：
2021-01-23
影响因子：
3.9
通讯作者：
Mannelli F
中科院分区：
文献类型：
--
作者：
Mannelli F
在骨髓增生性肿瘤的病程中，向急变期的演变是一个经常不可预测的，几乎总是致命的事件。原始细胞转化的分子机制尚未阐明，控制白血病发生的特定遗传和表观遗传事件仍不清楚。通过渐进的遗传步骤，长期持续的动态的结果是出现一个或多个克隆，其通常以复杂的遗传学为特征，无论是在常规核型分析中还是在现代高通量测序分析中，具有所有临床和预后相关性。目前的治疗方法在很大程度上是不够的，不能改变固有的不利结果。从这个角度来看，应用有针对性的策略应旨在防止白血病演变的发生。在转化时，治疗的关键目标应该是为符合条件的患者分配异基因移植。考虑到这一点，新的联合治疗可能提供有用的桥接策略，除了可能改善不适合强化治疗的患者的结局。
The evolution to blast phase is a frequently unpredictable and almost invariably fatal event in the course of myeloproliferative neoplasms. The molecular mechanisms underlying blast transformation have not been elucidated and the specific genetic and epigenetic events governing leukemogenesis remain unclear. The result of the long-lasting dynamics, passing through progressive genetic steps, is the emergence of one or more clones often characterized by complex genetics, either at conventional karyotyping or at modern high-throughput sequencing analyses, with all clinical and prognostic correlates. The current therapeutic approaches are largely inadequate and incapable of modifying the inherent unfavorable outcome. In this perspective, the application of targeted strategies should aim to prevent the occurrence of leukemic evolution. At transformation, the crucial target of treatment should be the allocation to allogeneic transplant for eligible patients. With this in mind, novel combination treatments may provide useful bridging strategies, beyond potentially improving outcomes for patients who are not candidates for intensive approaches.
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影响因子：
11.2
作者：
Abdel-Wahab O;Manshouri T;Patel J;Harris K;Yao J;Hedvat C;Heguy A;Bueso-Ramos C;Kantarjian H;Levine RL;Verstovsek S
通讯作者：
Verstovsek S
影响因子：
2.1
作者：
Guerra, Veronica A.;DiNardo, Courtney;Konopleva, Marina
通讯作者：
Konopleva, Marina
影响因子：
2.7
作者：
Lancman, Guido;Brunner, Andrew;Hobbs, Gabriela
通讯作者：
Hobbs, Gabriela
影响因子：
12.8
作者：
Estey, Elihu H.
通讯作者：
Estey, Elihu H.
DOI：
10.3324/haematol.2010.029306
发表时间：
2010-12-01
期刊：
HAEMATOLOGICA-THE HEMATOLOGY JOURNAL
影响因子：
--
作者：
Beer, Philip A.;Ortmann, Christina A.;Green, Anthony R.
通讯作者：
Green, Anthony R.