Hemorrhagic Transformation in Ischemic Stroke and the Role of Inflammation.
Hemorrhagic Transformation in Ischemic Stroke and the Role of Inflammation.
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DOI：
10.3389/fneur.2021.661955
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发表时间：
2021
影响因子：
3.4
通讯作者：
Jickling GC
中科院分区：
文献类型：
--
作者：
Spronk E;Sykes G;Falcione S;Munsterman D;Joy T;Kamtchum-Tatuene J;Jickling GC
出血性转化（HT）是急性缺血性脑卒中患者常见的并发症。缺血性中风后，外周血通过血脑屏障（BBB）外渗进入大脑。预防HT很重要，因为它会恶化卒中结果并增加死亡率。与HT风险增加相关的因素包括卒中严重程度、再灌注治疗（溶栓和取栓）、高血压、高血糖和年龄。炎症和免疫系统是血脑屏障破坏和HT的重要因素，并且与许多HT的危险因素有关。在这篇综述中，我们介绍了在再灌注治疗、高血压、高血糖和年龄的背景下炎症和免疫激活与HT的关系。讨论了与HT相关的炎症途径的差异。本文介绍了炎症对HT风险分层的作用以及针对免疫系统降低HT风险的治疗方法。
Hemorrhagic transformation (HT) is a common complication in patients with acute ischemic stroke. It occurs when peripheral blood extravasates across a disrupted blood brain barrier (BBB) into the brain following ischemic stroke. Preventing HT is important as it worsens stroke outcome and increases mortality. Factors associated with increased risk of HT include stroke severity, reperfusion therapy (thrombolysis and thrombectomy), hypertension, hyperglycemia, and age. Inflammation and the immune system are important contributors to BBB disruption and HT and are associated with many of the risk factors for HT. In this review, we present the relationship of inflammation and immune activation to HT in the context of reperfusion therapy, hypertension, hyperglycemia, and age. Differences in inflammatory pathways relating to HT are discussed. The role of inflammation to stratify the risk of HT and therapies targeting the immune system to reduce the risk of HT are presented.
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