Effect of osmolality on arginine vasopressin and renin release after hemorrhage.
Effect of osmolality on arginine vasopressin and renin release after hemorrhage.
复制标题
渗透压对出血后精氨酸加压素和肾素释放的影响。
DOI：
10.1152/ajpendo.1980.238.1.e62
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发表时间：
1980
期刊：
影响因子：
--
通讯作者：
D. Fisher
中科院分区：
文献类型：
--
作者：
R. Weitzman;A. Reviczky;T. H. Oddie;D. Fisher
在清醒犬正常水化、脱水、水负荷和高渗盐水输注条件下，观察血浆渗透压的变化对分级失血后血浆精氨酸加压素(AVP)和肾素活性(PRA)的影响。基线血浆渗透压和AVP在四个治疗组之间有显著差异；然而，出血后对数AVP的增加没有显著差异。一个意想不到的发现是，水负荷导致PRA和血浆醛固酮浓度显著升高，而血浆渗透压和AVP降低。在出血前，水负荷和脱水组的PRA显著大于正常水化或生理盐水组；在出血后，所有四个治疗组的对数PRA增加没有显著差异。这些数据表明，尽管渗透压的改变会影响基线水平的AVP，但对出血后AVP的相对(对数)升高没有影响。同样，AVP的改变可能会影响基线PRA，但不会影响出血后PRA的相对上升。
The effects of alterations of plasma osmolality on plasma arginine vasopressin (AVP) and renin activity (PRA) following graded hemorrhage were studied in conscious dogs who were either euhydrated, dehydrated, water loaded, or infused with hypertonic saline. Base-line plasma osmolality and AVP were significantly different in the four treatment groups; however, following hemorrhage the increases in log AVP did not significantly differ. An unexpected finding was that water loading resulted in significant elevations in PRA and plasma aldosterone concentrations, whereas plasma osmolality and AVP were reduced. Prior to hemorrhage, PRA was significantly greater in the water-loaded and dehydrated groups than in the euhydrated or saline-infused groups; following hemorrhage the increases in log PRA were not significantly different in all four treatment groups. The data suggest that, although alterations in osmolality influence base-line levels of AVP, they have no effect on relative (logarithmic) rises in AVP following hemorrhage. Similarly, alterations in AVP may influence base-line PRA, but do not influence relative rises in PRA following hemorrhage.