The androgen receptor is selectively involved in organization of sexually dimorphic social behaviors in mice
The androgen receptor is selectively involved in organization of sexually dimorphic social behaviors in mice
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DOI：
10.1210/en.2008-0183
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发表时间：
2008-08-01
期刊：
影响因子：
4.8
通讯作者：
Rissman, Emilie F.
中科院分区：
文献类型：
--
作者：
Bodo, Cristian;Rissman, Emilie F.
性二形神经区域在发育过程中是由类固醇激素组织的。在许多物种中，新生的雄性比它们的雌性同伴接触到更多的睾丸激素，最终是由睾丸激素芳香化产生的雌二醇影响了性别分化。然而，雄激素受体在大脑和行为的男性化中也起着重要作用。在这里，我们通过在雌性小鼠出生当天（PN0）用双氢睾酮（DHT）治疗雌性小鼠，验证了性别二态性社会和气味偏好行为可以在发育过程中由非芳香化雄激素区分的假设。对照小鼠单次注射PN0。成年人接受了性腺切除术，用雌二醇治疗，并测试了社会行为。与对照雌性相比，经DHT处理的雌性和雄性对照组一样，表现出对雌性和雄性脏的被褥的偏好，对雌性和雄性的偏好，暴露于雄性脏的被褥后，几个神经区域的c- fos免疫反应性（ir）降低。而在PN0上用DHT治疗的雌鼠，其性行为正常。视前区calbindin-ir细胞的数量呈两性二态（雄性多于雌性），但在PN0上给予DHT的雌性calbindin-ir神经元数量中等，与对照雄性和雌性无显著差异。我们的数据表明，围产期DHT可以影响小鼠的社会和嗅觉偏好组织，并支持雄激素受体在大脑和行为的性别分化组织中的作用。
It is well established that sexually dimorphic neural regions are organized by steroid hormones during development. In many species, neonatal males are exposed to more testosterone than their female littermates, and ultimately it is the estradiol, produced by aromatization of testosterone, that affects sexual differentiation. However, the androgen receptor also plays an important role in the masculinization of brain and behavior. Here we tested the hypothesis that sexually dimorphic social and odor preference behaviors can be differentiated by a nonaromatizable androgen during development by treating female mice on the day of birth (PN0) with dihydrotestosterone (DHT). Control mice received a single vehicle injection on PN0. Adults were gonadectomized, treated with estradiol, and tested for social behaviors. In contrast with control females, females treated on PN0 with DHT, like male controls, exhibited a preference for female-soiled vs. male-soiled bedding, a preference to investigate a female vs. a male and reduced c-Fos-immunoreactivity (ir) in several neural areas after exposure to male-soiled bedding. However, females treated with DHT on PN0 had normal female-typical sexual behavior. The number of calbindin-ir cells in the preoptic area is sexually dimorphic (males more than females), but females given DHT on PN0 had intermediate numbers of calbindin-ir neurons, not significantly different from control males or females. Our data demonstrate that organization of social and olfactory preferences in mice can be affected by perinatal DHT and lends support to the role of androgen receptor in organization of sexual differentiation of brain and behaviors.