KIR genes polymorphism in Argentinean Caucasoid and Amerindian populations
KIR genes polymorphism in Argentinean Caucasoid and Amerindian populations
复制标题
DOI：
10.1111/j.1399-0039.2007.00824.x
复制
发表时间：
2007-06-01
期刊：
影响因子：
--
通讯作者：
Fainboim, L.
中科院分区：
文献类型：
--
作者：
Flores, A. C.;Marcos, C. Y.;Fainboim, L.
在自然杀伤细胞中，杀伤免疫球蛋白样受体（KIRs）基因座编码抑制受体或激活受体，根据每个个体中存在的基因数量，有可能在群体中确定高多态性率。我们采用聚合酶链反应-序列特异性寡核苷酸探针对阿根廷北部的402个阿根廷高加索人和两个美洲印第安人（101个Wichis和54个Chiriguanos）进行了KIR分型。KIR2DL4、KIR3DL2、KIR3DL3和KIR3DP1均存在，而KIR2DL1、KIR2DL3、KIR2DS4、KIR3DL1和KIR2DP1的频率在84% ~ 96%之间。KIR2DS2、KIR2DL2、KIR2DL5、KIR2DS5、KIR2DS1和KIR3DS1的频率在41% ~ 62%之间。KIR2DS3在阿根廷高加索人群中的频率为29%，在美洲印第安人群中的频率很低。在10个Wichi家族中进行的单倍型分离研究表明，仅存在3种单倍型：A， B5和B1。在KIR2DS3、KIR2DS4全长基因和KIR2DL4等位基因的频率方面，美洲印第安人与亚洲人有一些相似之处，但与高加索人没有相似之处。
In natural killer cells, killer immunoglobulin-like receptors (KIRs) loci code for either inhibitory or activating receptors, and according to the number of genes present in each individual, it is possible to identify a high rate of polymorphism in the populations. We performed KIR typing by polymerase chain reaction-sequence-specific oligonucleotide probing in 402 Argentinean Caucasoid and in two Amerindian populations (101 Wichis and 54 Chiriguanos) from the North of Argentina. KIR2DL4, KIR3DL2, KIR3DL3 and KIR3DP1 were always present, whereas the frequencies of KIR2DL1, KIR2DL3, KIR2DS4, KIR3DL1 and KIR2DP1 ranged between 84% and 96%. The frequencies of KIR2DS2, KIR2DL2, KIR2DL5, KIR2DS5, KIR2DS1 and KIR3DS1 ranged between 41% and 62%. The KIR2DS3 with a frequency of 29% in Argentinean Caucasoid population was present at a very low frequency in Amerindian populations. Haplotype segregation studies performed in 10 Wichi families showed the presence of only three haplotypes: A, B5 and B1. The Amerindian populations showed several similarities to Asian but not to Caucasoid populations with regard to the frequency of KIR2DS3, full-length KIR2DS4 gene and KIR2DL4 alleles.