Trajectories of overweight and body mass index in adulthood and blood pressure at age 53: the 1946 British birth cohort study
Trajectories of overweight and body mass index in adulthood and blood pressure at age 53: the 1946 British birth cohort study
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DOI：
10.1097/hjh.0b013e328335de7b
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发表时间：
2010-04-01
影响因子：
4.9
通讯作者：
Kuh, Diana J.
中科院分区：
文献类型：
--
作者：
Wills, Andrew K.;Hardy, Rebecca J.;Kuh, Diana J.
目的探讨成年期超重类型与53岁时收缩压（SBP）和舒张压（DBP）的关系。在20、26、36、43和53岁时获得体重指数（BMI）。使用考虑药物的删失回归模型来调查53岁时的BP与每个年龄的超重（BMI>25 kg/m2）、首次超重的年龄和条件性体重增加的相关性。结果除20岁男性外，所有年龄段的超重与53岁时的血压呈正相关。在调整了当前的BMI后，只有43岁时的超重包含了男性血压的额外信息。26岁时超重的男性的SBP比53岁时首次超重的男性高8.7 mmHg [95%置信区间（CI）4.4-13.0]。在女性中观察到类似的模式，但关联较小[P（相互作用）]
Objective To assess the relationship between patterns of overweight during adulthood and systolic (SBP) and diastolic (DBP) blood pressure (BP) at age 53.Method Data are from 3035 male and female participants of the 1946 British birth cohort study. Body mass index (BMI) was obtained at ages 20, 26, 36, 43 and 53 years. Censored regression models accounting for medication were used to investigate associations of BP at 53 years with overweight (BMI>25 kg/m(2)) at each age, age at first overweight and conditional weight gain. Sex interactions were also examined.Results Overweight at all ages except for 20 years in men was positively associated with BP at 53 years. After adjusting for current BMI, only overweight at age 43 contained additional information on BP in men. Men who were overweight at age 26 had a SBP 8.7 mmHg higher [95% confidence interval (CI) 4.4-13.0] than those first overweight at 53 years. Similar patterns but smaller associations were seen in women [P(interaction)