Anti-AIDS agents, 3. Inhibitory effects of colchicine derivatives on HIV replication in H9 lymphocyte cells.
Anti-AIDS agents, 3. Inhibitory effects of colchicine derivatives on HIV replication in H9 lymphocyte cells.
复制标题
抗艾滋病药物，3.秋水仙碱衍生物对H9淋巴细胞中HIV复制的抑制作用。
DOI：
10.1021/np50074a052
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发表时间：
1991
影响因子：
5.1
通讯作者：
Lee,KH
中科院分区：
文献类型：
--
作者：
Tatematsu,H;Kilkuskie,RE;Corrigan,AJ;Bodner,AJ;Lee,KH
一系列秋水仙碱和异秋水仙碱衍生物被评价为HIV在H9淋巴细胞中复制的抑制剂。以治疗指数(IC50/EC50)衡量，秋水仙碱在无毒性的情况下仅显示非常轻微的抑制作用。在没有毒性的情况下，这些衍生物都不能抑制艾滋病毒的复制。
A series of colchicine and isocolchicine derivatives were evaluated as inhibitors of HIV replication in H9 lymphocytes. Colchicine showed only very slight inhibition in the absence of toxicity, as measured by the therapeutic index (IC50/EC50). None of the derivatives inhibited HIV replication in the absence of toxicity.