Social Isolation and Stress-related Cardiovascular, Lipid, and Cortisol Responses
Social Isolation and Stress-related Cardiovascular, Lipid, and Cortisol Responses
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DOI：
10.1007/s12160-009-9081-z
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发表时间：
2009-02-01
影响因子：
3.8
通讯作者：
Steptoe, Andrew
中科院分区：
文献类型：
--
作者：
Grant, Nina;Hamer, Mark;Steptoe, Andrew
社会支持是健康结果的一个强有力和一致的预测因素，而社会孤立预示着发病率和死亡率的增加。调解过程还没有被完全理解。该研究的目的是调查社会隔离与实验室急性压力下心血管和脂质反应之间的关系，以及一天中的皮质醇谱。来自Whitehall II队列的238名健康中年男性和女性对急性应激任务的心血管和脂质反应以及唾液皮质醇监测进行了研究。社会隔离是用一种改编版的亲密人士问卷来测量的。社会隔离与男性和女性任务后收缩压恢复较慢有关，只有男性对压力的胆固醇反应较高，而且男性和女性在一天中都有较大的皮质醇唤醒反应和更多的皮质醇输出。社会隔离对心血管疾病风险的影响可能是通过心血管、代谢和神经内分泌过程的应激相关失调来介导的。
Social support is a strong and consistent predictor of health outcomes, and social isolation predicts increased morbidity and mortality. The mediating processes are not completely understood.The purpose of the study is to investigate associations between social isolation and cardiovascular and lipid responses to acute stress in the laboratory, and cortisol profiles over the day.Cardiovascular and lipid responses to acute stress tasks, and salivary cortisol monitoring, were carried out in 238 healthy middle-aged men and women from the Whitehall II cohort. Social isolation was measured using an adapted version of the Close Persons Questionnaire.Social isolation was associated with slower post-task recovery of systolic blood pressure in men and women, a higher cholesterol response to stress in men only, and also with larger cortisol awakening responses and greater cortisol output over the day in both men and women.The impact of social isolation on cardiovascular disease risk may be mediated through stress-related dysregulation of cardiovascular, metabolic, and neuroendocrine processes.