HMGB1 in kidney diseases
HMGB1 in kidney diseases
复制标题
HMGB1在肾脏疾病中的作用
DOI：
10.1016/j.lfs.2020.118203
复制
发表时间：
2020
期刊：
影响因子：
6.1
通讯作者：
Ying Yao
中科院分区：
文献类型：
--
作者：
Zhi Zhao;Zhizhi Hu;Rui Zeng;Ying Yao
高迁移率族蛋白 1 (HMGB1) 是一种高度保守的核蛋白，参与多种生物过程，众所周知，它会作为细胞外环境中的损伤相关分子模式 (DAMP) 触发免疫反应。 HMGB1 由于其在不同亚细胞位置的多种功能，其作用是不同的。在细胞核中，HMGB1 作为伴侣来调节 DNA 事件，包括 DNA 复制、修复和核小体稳定性。在细胞质中，它参与调节自噬和凋亡。大量研究探讨了其在肾脏疾病发病机制中的作用。本综述主要关注 HMGB1 的作用，并总结了针对 HMGB1 在各种肾脏疾病中的通路和治疗，这可能为在这些病理条件下开发理想的治疗目的打开机会之窗。
High mobility group box 1 (HMGB1) is a highly conserved nucleoprotein involving in numerous biological processes, and well known to trigger immune responses as the damage-associated molecular pattern (DAMP) in the extracellular environment. The role of HMGB1 is distinct due to its multiple functions in different subcellular location. In the nucleus, HMGB1 acts as a chaperone to regulate DNA events including DNA replication, repair and nucleosome stability. While in the cytoplasm, it is engaged in regulating autophagy and apoptosis. A great deal of research has explored its function in the pathogenesis of renal diseases. This review mainly focuses on the role of HMGB1 and summarizes the pathway and treatment targeting HMGB1 in the various renal diseases which may open the windows of opportunities for the development of desirable therapeutic ends in these pathological conditions.