Bridging the gap between collective motility and epithelial-mesenchymal transitions through the active finite voronoi model.
Bridging the gap between collective motility and epithelial-mesenchymal transitions through the active finite voronoi model.
复制标题
通过主动有限泰森模型弥合集体运动和上皮间质转化之间的差距。
DOI：
10.1039/d3sm00327b
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发表时间：
2023
期刊：
影响因子：
3.4
通讯作者：
Bi,Dapeng
中科院分区：
文献类型：
--
作者：
Huang,Junxiang;Levine,Herbert;Bi,Dapeng
我们介绍了一个积极的版本，最近提出的有限Voronoi模型的上皮组织。由此产生的活动有限Voronoi（AFV）模型能够在存在活动细胞的情况下研究融合和非融合的几何形状以及它们之间的过渡。我们的研究确定了六个不同的阶段，其特征在于聚集-分离，动态干扰-解除干扰和上皮-间充质转化（EMT），从而将行为扩展到先前研究的基于顶点的模型中观察到的行为之外。具有丰富相图的AFV模型提供了一个有凝聚力的框架，该框架通过EMT实现的复杂动力学将通过解干扰而观察到的集体运动的进展统一起来。这种方法应该证明是有用的挑战，在发育生物学系统以及复杂的背景下，癌症转移。并给出了仿真代码。
We introduce an active version of the recently proposed finite Voronoi model of epithelial tissue. The resultant Active Finite Voronoi (AFV) model enables the study of both confluent and non-confluent geometries and transitions between them, in the presence of active cells. Our study identifies six distinct phases, characterized by aggregation–segregation, dynamical jamming–unjamming, and epithelial–mesenchymal transitions (EMT), thereby extending the behavior beyond that observed in previously studied vertex-based models. The AFV model with rich phase diagram provides a cohesive framework that unifies the well-observed progression to collective motility via unjamming with the intricate dynamics enabled by EMT. This approach should prove useful for challenges in developmental biology systems as well as the complex context of cancer metastasis. The simulation code is also provided.