The reproducibility of deep-inspiration breath-hold 18F-FDG PET/CT technique in diagnosing various cancers affected by respiratory motion
The reproducibility of deep-inspiration breath-hold 18F-FDG PET/CT technique in diagnosing various cancers affected by respiratory motion
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DOI：
10.1007/s12149-010-0352-3
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发表时间：
2010-04-01
影响因子：
2.6
通讯作者：
Kawai, Keiichi
中科院分区：
文献类型：
--
作者：
Nagamachi, Shigeki;Wakamatsu, Hideyuki;Kawai, Keiichi
深吸气屏气PET/CT（DIBH PET/CT）技术改善了诊断位于受呼吸运动影响的区域中的病变的局限性，呼吸运动导致PET和CT之间因呼吸引起的空间配准不良。然而，它的重复性方面的计算最大标准化摄取值（SUVmax）和代谢体积（MV）在DIBH PET/CT还没有阐明。本研究的目的是调查的重复性DIBH PET/CT技术，包括计算SUVmax和MV。60例患者与各种癌症。受试者有47个腹部病变和28个胸部病变。所有患者在静脉输注FDG后50分钟拍摄的早期全身图像中均显示配准错误。我们在第一次图像后40分钟添加延迟点图像。在延迟图像上，我们进行了传统的非屏气（NBH）技术和DIBH技术。在四次DIBH技术中，我们求出了计算这些指标的变异系数（CV），DIBH法的SUVmax值比NBH法提高了16.1-60.1%。胸部病变的CV平均值为5.5，腹部病变的CV平均值为6.3。DIBH法测得的MV值比NBH法测得的MV值降低14.0-20.1%。在重复性方面，胸部病变的CV平均值为7.1，腹部病变为11.9。DIBH技术改善了SUVmax和MV的不准确定量。虽然DIBH技术的SUVmax CV值在胸部病变中优于腹部病变，但其重复性是可以接受的。
The deep-inspiration breath-hold PET/CT (DIBH PET/CT) technique improves the limitations of diagnosing a lesion located in an area influenced by respiratory motion that results in spatial misregistrations caused by respiration between PET and CT. However, its reproducibility with regard to calculating the maximal standardized uptake value (SUVmax) and metabolic volume (MV) in DIBH PET/CT has not been elucidated.The purpose of this study was to investigate the reproducibility of the DIBH PET/CT technique including calculating the SUVmax and the MV.Sixty patients with various cancers were enrolled. The subjects had 47 abdominal lesions and 28 chest lesions. All patients demonstrated a misregistered image in the early whole-body image taken 50 min after FDG intravenous infusions. We added the delayed spot images 40 min after the first image. On the delayed image, we performed both conventional techniques with non-breath-hold (NBH) and the DIBH technique. In the four times DIBH technique, we obtained the coefficient of variance (CV) in calculating these indices for evaluating reproducibility.The SUVmax value with DIBH showed an increase of 16.1-60.1% compared with that measured by NBH. The mean value of CV was 5.5 in thoracic lesions and 6.3 in abdominal lesions. The values of MV with DIBH showed a decrease of 14.0-20.1% compared with those measured by NBH. Regarding reproducibility, mean value of CV was 7.1 in thoracic lesions and 11.9 in abdominal lesions.The DIBH technique improves the inaccurate quantification of both SUVmax and MV. Although the CV value of SUVmax with DIBH technique is better in thoracic lesions compared with that in abdominal lesions, the reproducibility was acceptable.