Total synthesis of (+)-tubelactomicin A. 2. Synthesis of the upper-half segment and completion of the total synthesis.
Total synthesis of (+)-tubelactomicin A. 2. Synthesis of the upper-half segment and completion of the total synthesis.
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DOI：
10.1021/ol050763x
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发表时间：
2005-04
期刊：
影响因子：
5.2
通讯作者：
Toru Motozaki;Kiyoto Sawamura;A. Suzuki;K. Yoshida;T. Ueki;Aiko Ohara;R. Munakata;K. Takao;K. Tadano
中科院分区：
文献类型：
--
作者：
Toru Motozaki;Kiyoto Sawamura;A. Suzuki;K. Yoshida;T. Ueki;Aiko Ohara;R. Munakata;K. Takao;K. Tadano
[反应：见正文]。我们完成了天然（+）-管乳霉素A（1）的全合成。这封信介绍了上半部分（C14-C24）的高效合成和完成的全合成，其特征是用于连接上半部分和下半部分的高产Stille偶联和用于构建1的整个结构的Mukaiyama大环内酯化。
[reaction: see text]. We have completed the total synthesis of natural (+)-tubelactomicin A (1), a 16-membered macrolide antibiotic. This Letter presents a highly efficient synthesis of the upper-half segment (C14-C24) and the completion of the total synthesis featuring a high-yielding Stille coupling for the connection of the upper-half and lower-half segments and Mukaiyama macrolactonization for the construction of the entire structure of 1.