Effect of errors in baseline optical properties on accuracy of transabdominal near-infrared spectroscopy in fetal sheep brain during hypoxic stress.
Effect of errors in baseline optical properties on accuracy of transabdominal near-infrared spectroscopy in fetal sheep brain during hypoxic stress.
复制标题
缺氧应激期间基线光学特性误差对胎羊脑经腹近红外光谱准确性的影响。
DOI：
10.1117/1.2118730
复制
发表时间：
2005
影响因子：
3.5
通讯作者：
Leigh,JohnS
中科院分区：
文献类型：
--
作者：
Mawn,Theresa;Nioka,Shoko;Nijland,Mark;Bloy,Luke;Elliott,MarkA;Chance,Britton;Leigh,JohnS
A continuous-wave (cw) near-infrared spectroscopy (NIRS) instrument has been developed to noninvasively quantify fetal cerebral blood oxygen saturation. A linear Green’s function formulism was used to analytically solve the photon diffusion equation and extract the time-varying fetal tissue oxy- and deoxy-hemoglobin concentrations from the NIR measurements. Here we explored the accuracy with which this instrument can be expected to perform over a range of fetal hypoxic states. We investigated the dependence of this accuracy on the accuracy of the reference optical properties chosen based on the literature. The fetal oxygenation of a pregnant ewe model was altered via maternal aortic occlusion. The NIR cw instrument was placed on the maternal abdomen directly above the fetal head, continuously acquiring diffuse optical measurements. Blood was sampled periodically from the fetus to obtain fetal arterial saturationmeasurements from blood gas analysis. The NIRvalues were compared with the fetalmeasurements. Variations in the NIR results due to uncertainty in the reference optical properties were relatively small within the fetalrange of 30 to 80%. Under hypoxic conditions, however, the variability of the NIRcalculations with changes in the assumed reference properties became more significant.
