Co-expression of keratinocyte growth factor and K-sam is an independent prognostic factor in gastric carcinoma
Co-expression of keratinocyte growth factor and K-sam is an independent prognostic factor in gastric carcinoma
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DOI：
10.3892/or_00000297
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发表时间：
2009-04-01
期刊：
影响因子：
4.2
通讯作者：
Hirakawa, Kosei
中科院分区：
文献类型：
--
作者：
Toyokawa, Takahiro;Yashiro, Masakazu;Hirakawa, Kosei
已报道来自胃成纤维细胞的角质细胞生长因子（KGF）以旁分泌方式刺激具有K-samII扩增的硬癌细胞增殖。本研究旨在探讨胃癌组织中K-sam和KGF共表达的临床意义。用抗K-sam和KGF的抗体对136例原发性胃肿瘤进行染色。估计癌细胞上的K-sam表达和成纤维细胞上的KGF表达。分析K-sam和/或KGF表达与临床病理特征的关系。136例胃癌中42例（31%）K-sam表达阳性。K-SAM表达与硬癌呈正相关（P
Keratinocyte growth factor (KGF) from gastric fibroblasts have been reported to stimulate proliferation of scirrhous gastric cancer cells with K-samII amplification in a paracrine manner. The aim of this study was to evaluate the clinical significance of the co-expression of K-sam and KGF in gastric carcinomas. A total of 136 primary gastric tumors were investigated by staining with antibodies against K-sam and KGF. K-sam expression on cancer cells and KGF expression on fibroblasts was estimated. The relationship between the K-sam and/or KGF expression and the clinicopathological characteristics were analyzed. K-sam expression was positive in 42 (31%) of 136 gastric carcinomas. K-sam expression was positively correlated with scirrhous cancer (p