Risk factors and prognostic influence of infection in a single cohort of 87 adults with systemic lupus erythematosus
Risk factors and prognostic influence of infection in a single cohort of 87 adults with systemic lupus erythematosus
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DOI：
10.1136/ard.60.12.1141
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发表时间：
2001-12-01
影响因子：
27.4
通讯作者：
Guillevin, L
中科院分区：
文献类型：
--
作者：
Noël, V;Lortholary, O;Guillevin, L
Objectives-To describe infectious complications and analyse their risk factors and prognostic role in adults with systemic lupus erythematosus (SLE).Methods-A monocentric cohort of 87 adults with SLE (1960-1997) was studied to determine the risk factors for infection (disease activity evaluated by SLAM and SLEDAI scores, type of organ(s) involved or any biological abnormality, specific treatments) by comparing patients who had suffered at least one infectious episode (n=35; 40%) with non-infected patients (n=52; 60%). Prognostic indicators were assessed by comparing survivors at 10 years with non-survivors.Results-Of the 57 infectious episodes, 47 (82%) were of bacterial origin, 16 (28%) were pneumonia, and 46 (81%) were community acquired. According to univariate analysis, significant risk factors for infection were: severe flares, lupus glomerulonephritis, oral or intravenous corticosteroids, pulse cyclophosphamide, and/or plasmapheresis. No predictors were identified at the time of SLE diagnosis. Multivariate analyses retained intravenous corticosteroids (p
