Therapeutic efficacy of the transplantation of isolated hepatocytes in rats with surgically induced acute hepatic failure: a study of the mechanism.
Therapeutic efficacy of the transplantation of isolated hepatocytes in rats with surgically induced acute hepatic failure: a study of the mechanism.
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离体肝细胞移植对手术诱发急性肝衰竭大鼠的治疗效果：机制研究。
DOI：
10.1159/000128500
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发表时间：
1986
期刊：
影响因子：
--
通讯作者：
H. Bismuth
中科院分区：
文献类型：
--
作者：
I. Demma;D. Houssin;M. Capron;M. Minato;J. Morin;M. Gigou;A. Székely;H. Bismuth
在这项研究中，肝细胞或脾细胞脾内移植的有益效果显示在动物与75%肝切除和门腔静脉分流，但没有在动物与肝血管阻断的总去肝。在75%肝切除及门腔静脉分流的动物中，注射肝细胞或脾细胞后，没有观察到吞噬活性的增强。这项研究证实了肝细胞治疗实验性肝衰竭的疗效，但表明非肝细胞可能同样有效。移植细胞的代谢活性和网状内皮系统吞噬活性的刺激可能不能解释移植细胞的治疗效果。
In this study, the beneficial effect of intrasplenic transplantation of hepatocytes or splenocytes was shown in animals with 75% hepatectomy and portacaval shunt but not in animals with total dehepatization by hepatic vascular exclusion. No enhancement of the phagocytic activity was observed in the animals with 75% hepatectomy and portacaval shunt after injection of hepatocytes or splenocytes. This study confirms the efficacy of hepatocytes for the treatment of experimental liver failure but shows that nonhepatic cells may be equally as effective. Metabolic activity of the transplanted cells and stimulation of the phagocytic activity of the reticuloendothelial system probably do not explain the therapeutic effect of the transplanted cells.