Overrepresentation of horizontal and vertical orientation preferences in developing ferret area 17
Overrepresentation of horizontal and vertical orientation preferences in developing ferret area 17
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DOI：
10.1073/pnas.95.5.2609
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发表时间：
1998-03-03
影响因子：
11.1
通讯作者：
Bonhoeffer, T
中科院分区：
文献类型：
--
作者：
Chapman, B;Bonhoeffer, T
视觉皮层组织的基本原理之一是神经元形成一个“地图”，其中相邻的细胞具有相似的方向偏好，以前的解剖学和成像研究表明，尽管这些方向偏好地图的确切布局在个体之间有所不同，但等方向域的特征（如宽度和间距）在物种内是恒定的。使用慢性光学成像的内在信号，我们现在证明，在雪貂区17皮质表面的较大比例是由水平和垂直轮廓比两个倾斜方向的反应为主。然而，有趣的是，我们发现过度表达的程度在个体动物之间存在显着差异，在一些年轻的雪貂中，对水平和垂直刺激的反应比对倾斜刺激的反应发展得更快，并且更大比例的皮层优先响应水平和垂直刺激，在其他个体中，对所有刺激的反应发展速度大致相同，水平和垂直偏好的过度表现相对较少。
One of the fundamental principles of visual cortical organization is that neurons form a "map" in which neighboring cells have similar orientation preferences, Previous anatomical and imaging studies have shown that although the exact layouts of these orientation preference maps vary between individuals, features of iso-orientation domains such as width and spacing appear constant within a species. Using chronic optical imaging of intrinsic signals we now demonstrate that in ferret area 17 a larger proportion of cortical surface is dominated by responses to horizontal and vertical contours than to the two oblique orientations. This was true for all ferrets studied both during development and in adulthood, Interestingly, however, we found that the degree of the overrepresentation varied significantly between individual animals, In some young ferrets, responses to horizontal and vertical stimuli developed faster than responses to oblique stimuli, and a much larger percentage of the cortex responded preferentially to horizontal and vertical stimuli, In other individuals, responses to all stimuli developed at roughly the same rate, and there was relatively little overrepresentation of horizontal and vertical preferences.