Circulating and Decidual Th17 Cell Levels in Healthy Pregnancy
Circulating and Decidual Th17 Cell Levels in Healthy Pregnancy
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DOI：
10.1111/j.1600-0897.2009.00771.x
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发表时间：
2010-02-01
影响因子：
3.6
通讯作者：
Saito, Shigeru
中科院分区：
文献类型：
--
作者：
Nakashima, Akitoshi;Ito, Mika;Saito, Shigeru
问题Th1/Th2 范式最近已被重建，以包括第三种细胞群：Th17 细胞。据报道，Th2型免疫主要存在于正常妊娠中。然而，妊娠期间Th17细胞的水平仍不清楚。我们调查了健康妊娠受试者的外周 Th17 细胞水平。研究方法为了评估 Th17 细胞的水平，我们使用流式细胞术调查了妊娠早期、中期和晚期妊娠受试者中产生 IL-17 的外周血单核细胞的比例。我们进一步研究了早期妊娠受试者中产生IL-17的蜕膜淋巴细胞的比例。结果大多数产生IL-17的细胞是CD4+T细胞。循环 Th17 细胞的数量在怀孕期间没有变化。在对正常妊娠早期受试者的配对t检验中，IL-17+蜕膜淋巴细胞的比例显着高于外周血淋巴细胞。结论正常妊娠期间外周血淋巴细胞Th17水平没有变化。
ProblemThe Th1/Th2 paradigm has recently been reconstituted to include a third population, Th17 cells. It has been reported that Th2 type immunity is predominantly present in normal pregnancy. However, the level of Th17 cells during pregnancy is still unclear. We investigated the level of peripheral Th17 cells in healthy pregnancy subjects.Method of studyTo evaluate the levels of Th17 cells, we investigated the proportion of peripheral blood mononuclear cells that produced IL-17 in the first, second, and third trimester pregnancy subjects using flow cytometry. We further studied the proportion of decidual lymphocytes that produced IL-17 in early pregnant subjects.ResultsMost of the IL-17-producing cells were CD4+ T cells. The number of circulating Th17 cells did not change during pregnancy. In a paired t-test of early normal pregnant subjects, the proportion of IL-17+ decidual lymphocytes was significantly higher than that of peripheral blood lymphocytes.ConclusionTh17 levels in peripheral blood lymphocytes do not change during normal pregnancy.