Intestinal tête-à-tête: helminths blunt immunity against flaviviruses.
Intestinal tête-à-tête: helminths blunt immunity against flaviviruses.
复制标题
肠道 täte-à-täte：蠕虫会削弱对黄病毒的免疫力。
DOI：
10.1038/s41422-021-00505-w
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发表时间：
2021
期刊：
影响因子：
44.1
通讯作者：
Kanneganti,Thirumala-Devi
中科院分区：
文献类型：
--
作者：
Place,DavidE;Kanneganti,Thirumala-Devi
众所周知，肠道蠕虫感染会改变宿主的免疫反应，但它们对嗜神经黄病毒的影响却知之甚少。Desai等人最近在Cell上发表的一项研究发现，蠕虫感染通过IL-4促进簇状细胞免疫反应，从而增加对随后由蚊子传播的黄病毒（西尼罗河病毒）攻击的易感性。蠕虫感染继续影响全球约15亿人，对人类健康造成重大影响。这些感染导致肠道疾病、营养不良、生长发育受损以及对其他感染的易感性改变。对蠕虫感染对宿主免疫的影响的兴趣稳步增长，因为一些蠕虫可以以预防免疫紊乱的方式扭曲宿主的免疫反应，包括哮喘、过敏和自身免疫性疾病。1在寄生虫感染常见的热带和亚热带地区，也经历了大量的蚊媒黄病毒感染，了解在合并感染的情况下，对寄生虫和病毒感染的免疫反应之间的复杂相互作用可能对治疗这些疾病具有重要意义。
Intestinal helminth infections are known to alter host immune responses, but their impact on neurotropic flaviviruses is poorly understood. A recent study in Cell by Desai et al. finds that helminth infection promotes a tuft cell immune response, via IL-4, that increases susceptibility to subsequent challenge by the mosquito-transmitted flavivirus, West Nile virus.Helminth infection continues to affect~ 1.5 billion people globally with significant consequences on human health. These infections cause intestinal disease, malnutrition, impaired growth and development, and altered susceptibility to other infections. Interest in the impact of helminth infection on host immunity has steadily grown, as some helminths can skew host immune responses in ways that prevent immune disorders including asthma, allergy, and autoimmune disease. 1 The tropical and subtropical regions where helminth infections are common also experience a large number of mosquito-borne flavivirus infections, and understanding the complex interplay between immune responses to parasitic helminth and viral infections in cases where co-infection occurs may have important implications for treating these diseases.