Collective Total Syntheses of Benzo[c]phenanthridine Alkaloids via a Sequential Transition Metal-Catalyzed Pot-Economic Approach
Collective Total Syntheses of Benzo[c]phenanthridine Alkaloids via a Sequential Transition Metal-Catalyzed Pot-Economic Approach
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DOI：
10.1021/acs.orglett.2c03278
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发表时间：
2022-11-07
期刊：
影响因子：
5.2
通讯作者：
Liu, Yongxiang
中科院分区：
文献类型：
--
作者：
Fu, Jiayue;Li, Bingbing;Liu, Yongxiang
苯并[c]菲啶类生物碱是从芸香科、罂粟科等植物中提取的异喹啉类生物碱，广泛分布于长江中下游地区。1自1839年首次分离到此类生物碱以来，迄今已分离出100多种生物碱，其代表性结构如图1所示。在其结构中，
Benzo[c]phenanthridine alkaloids that belong to the family of isoquinoline alkaloids are extracted from rutaceae, papaveraceae, and other plants, which are widely present in the middle and lower basins of the Yangtze River.1Since the first isolation of such alkaloids in 1839, more than 100 alkaloids have been isolated to date and representative structures are shown in Scheme 1. In their structures, the substituents of