PECAM-1: regulator of endothelial junctional integrity.
PECAM-1: regulator of endothelial junctional integrity.
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DOI：
10.1007/s00441-013-1779-3
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发表时间：
2014-03
影响因子：
3.6
通讯作者：
Newman, Peter J.
中科院分区：
文献类型：
--
作者：
Privratsky, Jamie R.;Newman, Peter J.
PECAM-1(也被称为CD31)是一种细胞黏附和信号受体，由六个细胞外免疫球蛋白(Ig)样同源结构域、一个短的跨膜结构域和一个118个氨基酸的细胞质结构域组成，该结构域在细胞激活时被磷酸化为丝氨酸和酪氨酸。PECAM-1的表达仅限于血液和血管细胞。在循环中的血小板和白细胞中，PECAM-1在很大程度上是一种抑制性受体，通过调节其胞浆区域的顺序磷酸化，限制细胞的激活反应。PECAM-1也在内皮细胞间连接处高表达，在那里它作为机械传感器，作为白细胞运输的调节器，并在维持内皮细胞连接完整性方面发挥作用。在这篇综述中，我们将描述(1)PECAM-1的功能结构域及其对其屏障增强特性的贡献，(2)PECAM-1的物理性质如何影响其亚细胞定位及其影响内皮细胞屏障功能的能力，(3)启动PECAM-1信号和/或内皮连接功能的各种刺激，以及(4)PECAM-1与其他连接分子的相互作用，从而影响内皮细胞的功能。
PECAM-1 (also known as CD31) is a cellular adhesion and signaling receptor comprised of six extracellular immunoglobulin (Ig) - like homology domains, a short transmembrane domain, and a 118 amino acid cytoplasmic domain that becomes serine and tyrosine phosphorylated upon cellular activation. PECAM-1 expression is restricted to blood and vascular cells. In circulating platelets and leukocytes, PECAM-1 functions largely as an inhibitory receptor that, via regulated sequential phosphorylation of its cytoplasmic domain, limits cellular activation responses. PECAM-1 is also highly expressed at endothelial cell intercellular junctions, where it functions as a mechanosensor, as a regulator of leukocyte trafficking, and in the maintenance of endothelial cell junctional integrity. In this review we will describe (1) the functional domains of PECAM-1 and how they contribute to its barrier-enhancing properties, (2) how the physical properties of PECAM-1 influence its subcellular localization and its ability to influence endothelial cell barrier function, (3) various stimuli that initiate PECAM-1 signaling and/or function at the endothelial junction, and (4) cross-talk of PECAM-1 with other junctional molecules, which can influence endothelial cell function.
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影响因子：
4
作者：
Dejana, Elisabetta;Orsenigo, Fabrizio;Lampugnani, Maria Grazia
通讯作者：
Lampugnani, Maria Grazia
影响因子：
6
作者：
Carrithers, M;Tandon, S;Madri, JA
通讯作者：
Madri, JA
DOI：
10.1161/atvbaha.112.252080
发表时间：
2012-08-01
影响因子：
8.7
作者：
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通讯作者：
Millan, Jaime
影响因子：
5.5
作者：
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通讯作者：
DeLisser, HM
影响因子：
4
作者：
Fleming, I;Fisslthaler, B;Busse, R
通讯作者：
Busse, R