Hexokinase-II expression in untreated oral squamous cell carcinoma: Comparison with FDG PET imaging
Hexokinase-II expression in untreated oral squamous cell carcinoma: Comparison with FDG PET imaging
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DOI：
10.1007/bf02984629
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发表时间：
2005-06
影响因子：
2.6
通讯作者：
M. Tian;Hong Zhang;T. Higuchi;N. Oriuchi;Yoshiki Nakasone;K. Takata;N. Nakajima;K. Mogi;K. Endo
中科院分区：
文献类型：
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作者：
M. Tian;Hong Zhang;T. Higuchi;N. Oriuchi;Yoshiki Nakasone;K. Takata;N. Nakajima;K. Mogi;K. Endo
己糖激酶被认为是细胞葡萄糖代谢的关键因子之一。本研究的目的是探讨HK-II在人口腔鳞状细胞癌（OSCC）中的表达与18F-fluoro-2-deoxy-D-glucose（FDG）摄取的关系。所有患者术前均于注射FDG后60 min行FDG正电子发射断层扫描（PET）。采用最大标准化摄取值（SUV）评价肿瘤FDG摄取。对肿瘤切片进行HK-II免疫化学染色。所有的肿瘤切片对HK-II染色呈阳性。HK-Ⅱ组18例（95%）肿瘤免疫染色阳性面积≥ 50%。HK-II结果显示11例（58%）肿瘤为强强度，6例（32%）为中等强度，2例（10%）为弱强度。SUV与HK-II表达之间无统计学显著相关性（p = 0.46）。总之，OSCC显示FDG积累增加和HK-II过度表达。然而，我们没有发现任何显着的关系，高FDG摄取和过度表达的HK-II在这个病人群体，因此其他属性需要进行评估，以阐明负责FDG活性的关键因素在口腔鳞癌。
Hexokinase is thought to be one of the key factors of glucose catabolism in the cell. The aim of this study was to investigate the relationship between HK-II expression and18F-fluoro-2-deoxy-D-glucose (FDG) uptake in human untreated oral squamous cell carcinoma (OSCC). Pre-operatively FDG positron emission tomography (PET) was performed 60 min after FDG injection in all the patients. Maximum standardized uptake value (SUV) was used for evaluation of tumor FDG uptake. Tumor sections were stained immunohistochemically for HK-II. All the tumor sections stained positive for HK-II. Eighteen (95%) tumors in HK-II showed immunostained positive area ≥50%. HK-II findings revealed eleven (58%) tumors with strong intensity, six (32%) with moderate intensity and two with weak intensity (10%). There was no statistically significant correlation between SUV and the expression of HK-II (p = 0.46). In conclusion, OSCC showed increased FDG accumulation and overexpression of HK-II. However, we did not find any significant relationship between high FDG uptake and overexpression of HK-II in this patient population, and thus other properties need to be evaluated in order to elucidate key factors responsible for FDG activity in OSCC.