Effect of probucol on the activity of postheparin plasma lipoprotein lipase and hepatic lipase.
Effect of probucol on the activity of postheparin plasma lipoprotein lipase and hepatic lipase.
复制标题
普罗布考对肝素后血浆脂蛋白脂肪酶和肝脂肪酶活性的影响。
DOI：
10.1016/0009-8981(81)90440-x
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发表时间：
1981
期刊：
影响因子：
--
通讯作者：
T. Strandberg
中科院分区：
文献类型：
--
作者：
T. Miettinen;J. Huttunen;T. Kuusi;T. Kumlin;S. Mattila;V. Naukkarinen;T. Strandberg
在10名参加冠心病一级预防计划的健康男性中研究了长期（34-56个月）普罗布考治疗对血脂、脂蛋白和肝素后血浆脂蛋白和肝脂酶活性的影响。停药后，观察到肝素后血浆脂蛋白脂肪酶活性、血清总胆固醇浓度以及高密度脂蛋白（HDL）胆固醇、HDL磷脂和载脂蛋白AI的血清浓度显著增加。血清甘油三酯水平或肝素后血浆肝脂酶活性未观察到变化。肝素后血浆肝脂酶活性与血清HDL浓度有相关性。血清HDL水平和肝素后血浆甘油三酯脂肪酶活性的个体变化之间不存在相关性。
The effect of oiscontinuation of long-term (34–56 months) probucol treatment on serum lipids, lipoproteins and on the activity of postheparin plasma lipoprotein and hepatic lipase has been studied in 10 healthy males participating in a primary prevention programme of coronary heart disease. A significant increase was observed in the activity of postheparin plasma lipoprotein lipase, in the total serum cholesterol concentration and in the serum concentrations of high density lipoprotein (HDL) cholesterol, HDL phospholipids and apoprotein AI after withdrawal of the drug. No changes were seen in the serum triglyceride levels or in the activity of postheparin plasma hepatic lipase. The activity of postheparin plasma hepatic lipase tended to correlate with the serum concentration of HDL. No correlations were present between the individual changes in the serum levels of HDL and in the activity of postheparin plasma triglyceride lipases.