Estimates of insulin sensitivity using glucose and C-Peptide from the hyperglycemia and adverse pregnancy outcome glucose tolerance test.
Estimates of insulin sensitivity using glucose and C-Peptide from the hyperglycemia and adverse pregnancy outcome glucose tolerance test.
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DOI：
10.2337/dc09-1463
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发表时间：
2010-03
期刊：
影响因子：
16.2
通讯作者：
Catalano PM
中科院分区：
文献类型：
--
作者：
Radaelli T;Farrell KA;Huston-Presley L;Amini SB;Kirwan JP;McIntyre HD;Catalano PM
确定作为高血压和不良妊娠结局（HAPO）研究的一部分获得的血糖和C肽值是否可用于估计妊娠晚期的胰岛素敏感性。本辅助研究共招募了78名入组HAPO研究的女性。静脉血浆样本在禁食8- 10小时后（时间0）和75 g葡萄糖激发后30、60、90和120 min采集，这在妊娠24-32周进行。分析样本的血糖、胰岛素和C肽。采用已建立的Matsuda和DeFronzo口服葡萄糖耐量试验胰岛素敏感性指数（ISOGTT）评估胰岛素敏感性。还根据其他两种常用的胰岛素敏感性指数（稳态模型评估[ISHOMA]和定量胰岛素敏感性检查指数[ISQUICKI]）计算胰岛素敏感性。使用0和60 min时的葡萄糖和C肽浓度计算新的胰岛素敏感性指数，以推导ISHOMA C-pep、ISQUICKI C-pep和ISOGTT C-pep。然后将这些指标与从ISOGTT估计的胰岛素敏感性相关。与ISOGTT相关性最强的是ISOGTT C-pep（r = 0.792，P < 0.001）。ISHOMA C-pep和ISQUICKI C-pep与ISOGTT的相关性也非常显著（分别为r = 0.676，P < 0.001和r = 0.707，P < 0.001）。这些数据表明，计算的ISOGTT C-pep是妊娠期胰岛素敏感性的良好预测因子，可用于估计参与HAPO研究的25，000多名女性的胰岛素敏感性。
To determine if glucose and C-peptide values obtained as part of the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) study could be used to estimate insulin sensitivity during late pregnancy. A total of 78 women enrolled in the HAPO study were recruited for this ancillary study. Venous plasma samples were drawn after an 8- to 10-h fast (time 0) and at 30, 60, 90, and 120 min after a 75-g glucose challenge, which was performed at 24–32 weeks' gestation. Samples were analyzed for plasma glucose, insulin, and C-peptide. Insulin sensitivity was estimated using the established Matsuda and DeFronzo insulin sensitivity index for oral glucose tolerance tests (ISOGTT). Insulin sensitivity was also calculated from two other commonly used indexes of insulin sensitivity (that for homeostasis model assessment [ISHOMA] and that for quantitative insulin sensitivity check index [ISQUICKI]). A new insulin sensitivity index was calculated using the glucose and C-peptide concentrations at 0 and 60 min to derive ISHOMA C-pep, ISQUICKI C-pep, and ISOGTT C-pep. These indexes were then correlated with insulin sensitivity estimated from the ISOGTT. The strongest correlation with the ISOGTT was obtained for ISOGTT C-pep (r = 0.792, P < 0.001). Further, the correlations of ISHOMA C-pep and ISQUICKI C-pep with ISOGTT were also significant (r = 0.676, P < 0.001 and r = 0.707, P < 0.001, respectively). These data suggest that calculated ISOGTT C-pep is an excellent predictor of insulin sensitivity in pregnancy and can be used to estimate insulin sensitivity in over 25,000 women participating in the HAPO study.
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影响因子：
7.7
作者：
Dabelea, D;Hanson, RL;Knowler, WC
通讯作者：
Knowler, WC
影响因子：
7.7
作者：
HAPO Study Cooperative Research Group
通讯作者：
HAPO Study Cooperative Research Group
影响因子：
8.2
作者：
MATTHEWS, DR;HOSKER, JP;TURNER, RC
通讯作者：
TURNER, RC
影响因子：
16.2
作者：
Kirwan, JP;Huston-Presley, L;Catalano, PM
通讯作者：
Catalano, PM
影响因子：
158.5
作者：
Crowther, CA;Hiller, JE;Robinson, JS
通讯作者：
Robinson, JS