Obesity Related Kidney Disease
Obesity Related Kidney Disease
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DOI：
10.2174/157339911794273928
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发表时间：
2011-01-01
影响因子：
3.3
通讯作者：
Sharma, Kumar
中科院分区：
文献类型：
--
作者：
Mathew, Anna V.;Okada, Shinichi;Sharma, Kumar
肥胖是新发疾病和现有慢性肾脏疾病并发症的危险因素。肥胖相关疾病的特征是蛋白尿、肾小球肿大和继发性局灶性肾小球硬化。传统上改变肾血流动力学引起超滤和上调的肾素血管紧张素系统已与这些变化。最近发现的由脂肪储存产生的循环因子如脂联素、瘦素和炎症标记物已显示直接影响肾小球中的细胞并引起病理变化。减轻体重、阻断肾素血管紧张素系统和恢复脂肪因子水平可能有益于改善肥胖相关疾病的进展。
Obesity is a risk factor for both de novo disease and as a complication of existing chronic kidney disease. Obesity related disease is characterized by albuminuria, glomerulomegaly and secondary focal glomerulosclerosis. Traditionally altered renal hemodynamics causing hyperfiltration and upregulated renin angiotensin system have been associated with these changes. Recently identified circulating factors produced by fat stores such as adiponectin, leptin and inflammatory markers have shown to directly affect the cells in the renal glomeruli and cause pathological changes. Weight loss, blockade of the renin angiotensin system and restoration of adipokine levels may be beneficial to ameliorate the progression of obesity related disease.