Intravenous Tirofiban Infusion After Angioplasty and Stenting in Intracranial Atherosclerotic Stenosis-Related Stroke
Intravenous Tirofiban Infusion After Angioplasty and Stenting in Intracranial Atherosclerotic Stenosis-Related Stroke
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DOI：
10.1161/strokeaha.120.033551
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发表时间：
2021-05-01
期刊：
影响因子：
8.3
通讯作者：
Park, Man Seok
中科院分区：
文献类型：
--
作者：
Baek, Byung Hyun;Yoon, Woong;Park, Man Seok
背景与目的：本研究旨在探讨颅内动脉粥样硬化性狭窄相关大血管闭塞性脑卒中患者行急诊血管成形术（加或不加支架置入术）后静脉输注替罗非班的有效性和安全性。方法：我们对98例接受血栓切除术后加或不加支架的血管成形术治疗颅内动脉粥样硬化性卒中的患者进行回顾性病例系列研究。狭窄相关的大血管闭塞。将患者分为2组：术后12小时持续静脉输注替罗非班（替罗非班静脉输注组，n=30）和术后未接受替罗非班静脉输注的组（对照组，n=68）。比较两组的以下治疗结果：计算机断层扫描血管造影显示治疗动脉早期再闭塞、实质血肿、症状性出血和 90 天功能结果。结果：18 名患者（18.4%）发生早期再闭塞。静脉注射替罗非班组的早期再闭塞率显着低于对照组（3.3% vs 25%，P
Background and Purpose:This study aimed to investigate the effectiveness and safety of intravenous infusion of tirofiban after emergent angioplasty with or without stenting in patients with intracranial atherosclerotic stenosis-related large-vessel occlusion stroke.Methods:We performed a retrospective case series study of 98 patients who underwent thrombectomy followed by angioplasty with or without stenting to treat intracranial atherosclerotic stenosis-related large-vessel occlusion. Patients were divided into 2 groups: those who received continuous intravenous infusion of tirofiban for 12 hours after procedure (intravenous tirofiban group, n=30) and those who did not receive postprocedural intravenous tirofiban (control group, n=68). The following treatment outcomes in the 2 groups were compared: early reocclusion of treated arteries on computed tomography angiography, parenchymal hematoma, symptomatic hemorrhage, and 90-day functional outcome.Results:Early reocclusion occurred in 18 patients (18.4%). The rate of early reocclusion was significantly lower in the intravenous tirofiban group than in the control group (3.3% versus 25%, P