Corpus Callosotomy: Clinical and Electroencephalographic Effects
Corpus Callosotomy: Clinical and Electroencephalographic Effects
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胼胝体切开术：临床和脑电图效应
DOI：
10.1111/j.1528-1157.1984.tb04194.x
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发表时间：
1984
期刊：
影响因子：
5.6
通讯作者：
R. Gumnit
中科院分区：
文献类型：
--
作者：
J. Gates;I. Leppik;Jessie Yap;R. Gumnit
摘要：6例（5男1女），年龄15 - 41岁（平均23岁），患有医学上难治性癫痫7-35年（平均15岁），接受了全胼胝体切除术（前连合至后连合），以治疗癫痫发作导致跌倒和受伤。术前脑电图显示两种或更多形态不同的间歇放电，其中至少一种是全身性的。在所有病例中记录了普遍化的癫痫发作，以解释导致损伤的临床癫痫发作。术前和术后唤醒状态下全身性癫痫样放电的比较显示，术后全身性放电的减少具有统计学意义（p < 0.05）。术后观察期从10个月到30个月不等（平均17.6个月），并记录有统计学意义（p < 0.05）的下降癫痫发作次数减少（平均：术前23.2次/月；术后0.7次/月）。未证实术前和术后全（全身性和局灶性）间期放电在统计学上有显著差异。我们的患者没有出现长期的、临床上明显的手术并发症。因此，胼胝体切片可阻断全面性癫痫样放电（如术后脑电图所示），通常可显著减少全面性癫痫发作。
Summary: Six persons (five male, one female), 15–41 years of age (mean, 23 years), with medically intractable epilepsy for 7–35 years (mean, 15 years) underwent total corpus callosum section (anterior commissure to posterior commissure) for treatment of seizures resulting in falls and injuries. Preoperative EEGs demonstrated two or more morphologically distinct interictal discharges, at least one of which was generalized. Generalized ictal EEG discharges were documented in all cases to account for the clinical seizures resulting in injury. A comparison of generalized epileptiform discharges in comparable states of arousal pre‐ and postoperatively demonstrated a statistically significant (p < 0.05) reduction of generalized discharges after surgery. Postoperative observation periods have ranged from 10 to 30 months (mean, 17.6 months) and have documented a statistically significant (p < 0.05) decrease in the number of falling seizures (means: preoperative, 23.2 seizures/month; postoperative, 0.7 seizures/month). A statistically significant difference in pre‐ and postoperative total (generalized and focal) interictal discharges was not demonstrated. Long‐term, clinically apparent complications of surgery did not occur in our patients. Thus, sectioning of the corpus callosum interrupts generalized epileptiform discharges (as documented by the postoperative EEG) and usually results in a significant decrease in generalized seizures.