Chlamydia abortus: New Aspects of Infectious Abortion in Sheep and Potential Risk for Pregnant Women
Chlamydia abortus: New Aspects of Infectious Abortion in Sheep and Potential Risk for Pregnant Women
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DOI：
10.1007/s40588-015-0014-2
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发表时间：
2015-03-01
影响因子：
5.2
通讯作者：
Longbottom, David
中科院分区：
文献类型：
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作者：
Essig, Andreas;Longbottom, David
流产衣原体(原鹦鹉热衣原体1型)是一种专性胞内生物，是引起羊流行性流产的主要原因。通过对流产线虫基因组序列的分析，发现了高度变异的蛋白质家族，包括跨膜头蛋白(TMH)/Inc.和多形膜蛋白(PMPs)。遗传和超微形态的线索表明，流产线虫利用3型分泌系统将效应蛋白输送到宿主细胞。在未怀孕的母羊中，相对较低剂量的感染性微生物会导致衣原体潜伏。一旦母羊怀孕，感染复发并引发胎盘感染和随之而来的流产。具有传染性的基本体在环境中脱落，并被接触动物的人吸入。孕妇可能会感染危及生命的流产球虫，导致败血症流产和死产。医生和兽医应提醒孕妇避免同时接触绵羊和山羊，特别是在产羔或开玩笑期间。
Chlamydia abortus (the former Chlamydia psittaci serotype 1) is an obligate intracellular organism and the world's leading cause of ovine enzootic abortion. Sequence analysis of the genome of C. abortus revealed highly variable protein families, including TMH (Trans-Membrane Head)/Inc and Pmps (Polymorphic Membrane Proteins). Genetic and ultramorphological hints suggest that C. abortus employs a type 3 secretion system to deliver effector proteins into the host cell. In non-pregnant ewes, relatively low doses of infectious organisms can induce chlamydial latency. Once the ewe becomes pregnant, infection recrudesces and initiates placental infection and resultant abortion. Infectious elementary bodies are shed in the environment and inhaled by people exposed to the animals. Pregnant women may develop life-threatening C. abortus infections, resulting in septic abortion and stillbirth. Physicians and veterinarians should alert pregnant women to avoid exposure to both sheep and goats, particularly during the lambing or kidding period.