OPPOSITE EFFECTS OF OXYTOCIN AND VASOPRESSIN ON AVOIDANCE-BEHAVIOR AND HIPPOCAMPAL THETA RHYTHM IN RAT
OPPOSITE EFFECTS OF OXYTOCIN AND VASOPRESSIN ON AVOIDANCE-BEHAVIOR AND HIPPOCAMPAL THETA RHYTHM IN RAT
复制标题
DOI：
10.1016/0028-3908(78)90107-7
复制
发表时间：
1978-01-01
影响因子：
4.7
通讯作者：
DEWIED, D
中科院分区：
文献类型：
--
作者：
BOHUS, B;URBAN, I;DEWIED, D
在单次学习试验后立即在脑室内给予催产素和精氨酸-8-抗利尿素（AVP），对被动回避行为的保留产生相反的影响。被动回避行为在催产素作用下呈剂量依赖性减弱，在AVP作用下呈促进作用。通过脑室内注射特异性抗血清来中和中枢循环的催产素和抗利尿激素后，发现了相反的效果。侧脑室注射后叶催产素可降低睡眠时产生的海马θ波节律的峰值频率。催产素抗血清增加了θ节律中较高频率的发生率。外周注射催产素模拟AVP对跳极回避行为消退的影响。当给予更高剂量的催产素时，观察到对灭绝的抵抗而不是促进灭绝。催产素对被动回避行为有促进或减弱的作用。中枢释放的催产素可能是一种自然产生的失忆症神经肽。
Intracerebroventricular administration of oxytocin and arginine-8-vasopressin (AVP), immmediately after a single learning trial, resulted in opposite effects on retention of passive avoidance behavior. Passive avoidance behavior was attenuated by oxytocin and facilitated by AVP in a dose-dependent manner. Reverse effects were found after neutralizing the centrally circulating oxytocin and vasopressin by intraventricular injection of specific antiserum to these peptides. Administration of oxytocin into a lateral ventricle resulted in a decrease of the peak frequency of hippocampal theta rhythm generated during paradoxical sleep episodes. Oxytocin antiserum increased the incidence of higher frequencies in the theta rhythm. Peripheral administration of oxytocin mimicked the effect of AVP on extinction of pole-jumping avoidance behavior. Resistance to extinction rather than facilitation of extinction was observed when higher doses of oxytocin were given. Passive avoidance behavior appeared to be either facilitated or attenuated after s.c. oxytocin administration. Centrally released oxytocin may be a naturally occurring amnesic neuropeptide.