High-fat or ethinyl-oestradiol intake during pregnancy increases mammary cancer risk in several generations of offspring.
High-fat or ethinyl-oestradiol intake during pregnancy increases mammary cancer risk in several generations of offspring.
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DOI：
10.1038/ncomms2058
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发表时间：
2012
影响因子：
16.6
通讯作者：
中科院分区：
文献类型：
--
作者：
母亲在怀孕期间暴露于环境因素会影响后代患许多慢性成人发病疾病的风险。在这里，我们调查了喂食高脂肪(HF)或乙炔雌二醇(EE2)补充饮食是否会影响女儿、孙女和曾孙女患致癌物诱发乳腺癌的风险。我们发现，在HF大鼠的子孙和EE2大鼠的子孙和曾孙中，乳腺肿瘤的发生更高。异交实验表明，乳腺癌风险的增加同样通过女性或男性生殖系传递给HF孙女，但它只通过女性生殖系传递给EE2孙女。母亲接触EE2对后代乳腺癌风险的影响与所有三代EE2后代乳腺组织DNA甲基化机制和甲基化模式的变化有关。我们得出结论，怀孕期间饮食和雌激素暴露增加了多代后代患乳腺癌的风险，可能是通过表观遗传手段。环境因素可以影响一个人对癌症的易感性，但目前尚不清楚这种影响是否会延伸到直接接触过的几代人之外。在这里，作者观察到，用高脂肪饮食或激素衍生品喂养怀孕的大鼠，在随后的三代人中，乳腺癌风险增加。
Maternal exposures to environmental factors during pregnancy influence the risk of many chronic adult-onset diseases in the offspring. Here we investigate whether feeding pregnant rats a high-fat (HF)- or ethinyl-oestradiol (EE2)-supplemented diet affects carcinogen-induced mammary cancer risk in daughters, granddaughters and great-granddaughters. We show that mammary tumourigenesis is higher in daughters and granddaughters of HF rat dams and in daughters and great-granddaughters of EE2 rat dams. Outcross experiments suggest that the increase in mammary cancer risk is transmitted to HF granddaughters equally through the female or male germ lines, but it is only transmitted to EE2 granddaughters through the female germ line. The effects of maternal EE2 exposure on offspring's mammary cancer risk are associated with changes in the DNA methylation machinery and methylation patterns in mammary tissue of all three EE2 generations. We conclude that dietary and oestrogenic exposures in pregnancy increase breast cancer risk in multiple generations of offspring, possibly through epigenetic means. Environmental factors can influence one's susceptibility to cancer, but it is not clear whether such an influence extends beyond the directly exposed generations. Here, feeding pregnant rats with a high-fat diet or a hormone derivative, the authors observe increased breast cancer risk in up to three subsequent generations.
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影响因子：
64.8
作者：
通讯作者：
--
DOI：
10.1073/pnas.96.17.9751
发表时间：
1999-08-17
影响因子：
11.1
作者：
Hsu, DW;Lin, MJ;Shen, CKJ
通讯作者：
Shen, CKJ
影响因子：
7.2
作者：
Huang, Tim H. -M.;Esteller, Manel
通讯作者：
Esteller, Manel
影响因子：
158.5
作者：
Hoover, Robert N.;Hyer, Marianne;Troisi, Rebecca
通讯作者：
Troisi, Rebecca
影响因子：
6.4
作者：
de Assis, Sonia;Khan, Galam;Hilakivi-Clarke, Leena
通讯作者：
Hilakivi-Clarke, Leena