ALKALOID SYNTHESIS VIA INTRAMOLECULAR ENE REACTION .2. APPLICATION TO DL-MESEMBRINE AND DL-DIHYDROMARITIDINE
ALKALOID SYNTHESIS VIA INTRAMOLECULAR ENE REACTION .2. APPLICATION TO DL-MESEMBRINE AND DL-DIHYDROMARITIDINE
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DOI：
10.1021/jo00346a028
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发表时间：
1982-01-01
影响因子：
3.6
通讯作者：
WEBB, RR
中科院分区：
文献类型：
--
作者：
KECK, GE;WEBB, RR
本文报道了红盆花属和石蒜属生物碱的全合成方法。在每种情况下的关键策略涉及适当构造的酰基亚硝基烯烃的分子内烯环化，得到环状异羟肟酸（烯产物）。
The total syntheses of mesembrine (2) and dihydromaritidine, alkaloids of the genera Sceletium and Amaryllis, respectively, are described. The key strategy in each case involves the intramolecular ene cyclization of an appropriately constructed acylnitroso olefin, giving cyclic hydroxamic acid (ene product).