Risk of cerebral palsy in Chinese children: A N:M matched case control study
Risk of cerebral palsy in Chinese children: A N:M matched case control study
复制标题
中国儿童脑瘫风险：N:M 匹配病例对照研究
DOI：
10.1111/jpc.13479
复制
发表时间：
2017-05-01
影响因子：
1.7
通讯作者：
Wang, Lina
中科院分区：
文献类型：
--
作者：
Gao, Jing;Zhao, Bin;Wang, Lina
目的：为探讨小儿脑性瘫痪（脑瘫）的流行病学危险因素，采用N：M配对病例对照研究方法，对114例脑瘫患儿和1286例正常对照进行分析。相关资料采用母亲自行设计的问卷进行收集。结果：单因素分析得到20个有意义的CP危险因素。高龄产妇（30岁或以上）（校正比值比（OR）1.63，95%置信区间（CI）0.98-2.72），妊娠期饮酒（调整OR 4.17，95%CI 1.23-14.08），居住在农村（调整OR 1.71，95% CI 1.18-2.48），父亲职业性接触有害物质多因素分析显示，多胎妊娠（调整OR 3.34，95% CI 1.61-6.93）和多胎妊娠（调整OR 3.10，95% CI 1.65-5.84）是CP的危险因素。另一方面，母亲受教育程度高（调整OR 0.60，95% CI 0.46-0.76），叶酸补充剂（调整OR 0.50，95%CI 0.30-0.82），以及高出生医院水平（校正OR 0.68，95%CI 0.52-0.90）为保护因素。虽然CP的重要危险因素集中在出生时妊娠和围产期事件，但如果考虑本研究中确定的潜在危险因素，其发病率可能会进一步降低。
Aim: To estimate epidemiological risk factors for cerebral palsy (CP) in children.Methods:A N:M matched case control study was conducted in 114 persons with CP and 1286 controls. Relevant data were collected using a maternal self-design questionnaire. Univariate logistic regression and multivariate conditional logistic regression analyses were performed using SPSS.Results: Univariate analysis has yielded 20 significant risk factors for CP. Advanced maternal age (30 years or older) at childbirth (adjusted odds ratio (OR) 1.63, 95% confidence interval (CI) 0.98-2.72), alcohol consumption during pregnancy (adjusted OR 4.17, 95% CI 1.23-14.08), living in the countryside (adjusted OR 1.71, 95% CI 1.18-2.48), father's occupational exposure to harmful substances (adjusted OR 3.34, 95% CI 1.61-6.93) and multiple births (adjusted OR 3.10, 95% CI 1.65-5.84) were found to be risk factors for CP by multivariate analysis. On the other side, high mother's education level (adjusted OR 0.60, 95% CI 0.46-0.76), folic acid supplements (adjusted OR 0.50, 95% CI 0.30-0.82), and high birth hospital level (adjusted OR 0.68, 95% CI 0.52-0.90) were found to be protective factors.Conclusion: Although the important risk factors of CP focus on gestation at birth and perinatal events, the incidence could probably be further lowered, if potential risk factors identified in this study are considered.