Expandable external support device to improve Saphenous Vein Graft Patency after CABG.
Expandable external support device to improve Saphenous Vein Graft Patency after CABG.
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可扩展的外部支撑装置可改善 CABG 后隐静脉移植物的通畅性。
DOI：
10.1186/1749-8090-8-122
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发表时间：
2013-05-06
影响因子：
1.6
通讯作者：
Bolotin G
中科院分区：
文献类型：
--
作者：
Ben-Gal Y;Taggart DP;Williams MR;Orion E;Uretzky G;Shofti R;Banai S;Yosef L;Bolotin G
隐静脉移植物的低通畅率仍然是手术血运重建术的主要困境。我们研究了一种新型的可扩展外部支持装置，旨在减轻早期和晚期移植物衰竭的致病因素。在这项研究中，14只成年羊接受了心脏血运重建术，每只羊使用两根静脉移植；一条通向前冠状动脉另一条通向钝缘动脉。一个移植物由该装置支撑，而另一个作为对照。靶血管在连续病例之间交替进行。动物接受即时和晚期血管造影，然后处死进行组织病理学评估。在研究的14只动物中，3只在手术期间死亡（与植入装置无关），10只在随访期间存活。存活动物中，3只移植物血栓形成，1只移植物闭塞，均为对照组（p = 0.043）。定量血管造影评估显示，两组间移植物即刻均匀性水平无差异，对照组的方差系数（CV%）为7.39，而支撑移植物组的方差系数（CV%）为5.07,p = 0.082。在12周时，对照移植物与支撑移植物存在显著的不均匀性（CV = 22.12 vs . 3.01, p < 0.002）。在组织病理学评估中，支持移植物的平均内膜面积显著低于对照移植物（11.2 mm^2 vs 23.1 mm^2 p < 0.02）。在CABG术后早期动物模型中，可扩展SVG外支撑系统可有效减少SVG的不均匀扩张和新生内膜形成。这项新技术可能有潜力提高外科心肌血运重建术后SVG的通畅率。
Low patency rates of saphenous vein grafts remain a major predicament in surgical revascularization. We examined a novel expandable external support device designed to mitigate causative factors for early and late graft failure. For this study, fourteen adult sheep underwent cardiac revascularization using two vein grafts for each; one to the LAD and the other to the obtuse marginal artery. One graft was supported with the device while the other served as a control. Target vessel was alternated between consecutive cases. The animals underwent immediate and late angiography and were then sacrificed for histopathologic evaluation. Of the fourteen animals studied, three died peri-operatively (unrelated to device implanted), and ten survived the follow-up period. Among surviving animals, three grafts were thrombosed and one was occluded, all in the control group (p = 0.043). Quantitative angiographic evaluation revealed no difference between groups in immediate level of graft uniformity, with a coefficient-of-variance (CV%) of 7.39 in control versus 5.07 in the supported grafts, p = 0.082. At 12 weeks, there was a significant non-uniformity in the control grafts versus the supported grafts (CV = 22.12 versus 3.01, p < 0.002). In histopathologic evaluation, mean intimal area of the supported grafts was significantly lower than in the control grafts (11.2 mm^2 versus 23.1 mm^2 p < 0.02). The expandable SVG external support system was found to be efficacious in reducing SVG’s non-uniform dilatation and neointimal formation in an animal model early after CABG. This novel technology may have the potential to improve SVG patency rates after surgical myocardial revascularization.
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DOI：
10.1016/0735-1097(96)00206-9
发表时间：
1996-09-01
影响因子：
24
作者：
FitzGibbon, GM;Kafka, HP;Burton, JR
通讯作者：
Burton, JR
影响因子：
4.3
作者：
Eslami, MH;Gangadharan, SP;Conte, MS
通讯作者：
Conte, MS
影响因子：
4.3
作者：
KOHLER, TR;KIRKMAN, TR;CLOWES, AW
通讯作者：
CLOWES, AW
影响因子：
82.9
作者：
Mehta, D;George, SJ;Angelini, GD
通讯作者：
Angelini, GD
DOI：
10.1097/00002480-199407000-00007
发表时间：
1994-07-01
期刊：
ASAIO journal (American Society for Artificial Internal Organs : 1992)
影响因子：
--
作者：
Trubel, W;Moritz, A;Polterauer, P
通讯作者：
Polterauer, P