Anterior cingulate cortex modulates preparatory activation during certain anticipation of negative picture
Anterior cingulate cortex modulates preparatory activation during certain anticipation of negative picture
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DOI：
10.1016/j.neuropsychologia.2007.08.006
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发表时间：
2008-12
期刊：
影响因子：
2.6
通讯作者：
K. Onoda;Y. Okamoto;Shigeru Toki;K. Ueda;K. Shishida;Akiko Kinoshita;Shinpei Yoshimura;H. Yamashita;S. Yamawaki
中科院分区：
文献类型：
--
作者：
K. Onoda;Y. Okamoto;Shigeru Toki;K. Ueda;K. Shishida;Akiko Kinoshita;Shinpei Yoshimura;H. Yamashita;S. Yamawaki
我们研究了神经激活与预期的情绪图片使用功能磁共振成像（fMRI）通过直接比较确定和不确定的预期条件。在用fMRI扫描的同时，健康参与者（n=18）被提示预测然后感知具有可预测（即，某些）情感效价（即，积极和消极），给定先前的线索，以及不确定效价（积极或消极）的线索刺激。负效价图片预期时，胼胝体上前扣带回、腹外侧前额叶、杏仁核和杏仁核的活动比不确定情绪预期时增强。这一结果表明，这些大脑区域参与了对负面图像的预期，并且预期的确定性可能会增强它们的活动水平。此外，胼胝体上前扣带皮层在特定的负性预期过程中与前额叶皮层、枕叶皮层和前额叶皮层表现出功能性连接。这些发现与一种解释是一致的，即由大脑前部区域产生的自上而下的调制参与了枕叶皮层内的某些负面预期。人们认为，涉及杏仁核、前扣带和前扣带的边缘系统参与了情绪过程，而涉及视觉皮层的输入系统则进入了一种空闲状态。
We studied the neural activation associated with anticipations of emotional pictures using functional magnetic resonance imaging (fMRI) by directly comparing certain with uncertain anticipation conditions. While being scanned with fMRI, healthy participants (n=18) were cued to anticipate and then perceive emotional stimuli having predictable (i.e., certain) emotional valences (i.e., positive and negative), given a preceding cue, as well as cued stimuli of uncertain valence (positive or negative). During anticipation of pictures with certain negative valence, activities of supracallosal anterior cingulate cortex, ventrolateral prefrontal cortex, insula, and amygdala were enhanced relative activity levels that for the uncertain emotional anticipation condition. This result suggests that these brain regions are involved in anticipation of negative images, and that their activity levels may be enhanced by the certainty of anticipation. Furthermore, the supracallosal anterior cingulate cortex showed functional connectivity with the insula, prefrontal cortex, and occipital cortex during the certain negative anticipation. These findings are consistent with an interpretation that top-down modulation, arising from anterior brain regions, is engaged in certain negative anticipation within the occipital cortex. It is thought that the limbic system involving the amygdala, ACC, and insula, engaged emotional processes, and that the input system involving the visual cortex entered an idling state.