Improvement of migraine with change from combined hormonal contraceptives to progestin-only contraception with desogestrel: How strong is the effect of taking women off combined contraceptives?
Improvement of migraine with change from combined hormonal contraceptives to progestin-only contraception with desogestrel: How strong is the effect of taking women off combined contraceptives?
复制标题
DOI：
10.1080/01443615.2016.1234438
复制
发表时间：
2017-04-01
影响因子：
1.3
通讯作者：
Gantenbein, Andreas R.
中科院分区：
文献类型：
--
作者：
Merki-Feld, Gabriele S.;Imthurn, Bruno;Gantenbein, Andreas R.
偏头痛是一种致残性头痛疾病，影响高达17%的女性人口。雌激素在月经周期或联合激素避孕药（CHC）使用者的无排卵间隔期间的撤药起着关键作用。两项基于日记的研究表明，仅孕激素药丸（POP）去氧孕烯75克对偏头痛发作频率和疼痛强度有积极影响。在这两项研究中，CHC使用者和非使用者都包括在内，这使得很难区分妇女脱离CHC的影响和POP本身的好处。在本研究中，我们比较了POP去氧孕烯75 g对当前CHC使用者和非使用者偏头痛的治疗效果。我们发现去氧孕烯对偏头痛的积极影响不仅在从CHCs转换为去氧孕烯的女性中，而且在那些在开始之前6个月没有使用激素的女性中也是如此。
Migraine is a disabling headache disorder, which affects up to 17% of the female population. Oestrogen withdrawal during the menstrual cycle or the hormone-free interval in users of combined hormonal contraceptives (CHC) plays a pivotal role. Two diary-based studies demonstrated a positive impact of the progestin-only pill (POP) desogestrel 75g on the frequency of the migraine attacks and pain intensity. In both studies, CHC users as well as nonusers were included, which makes it difficult to distinguish between the effect of taking women off the CHC and the benefit of the POP itself. With the present study, we compared the therapeutic effect of the POP desogestrel 75g on migraine in current CHC users and nonusers. We found a positive influence of desogestrel on migraine not only in women who switched from CHCs to desogestrel, but also in those who had not used hormones over 6 months before starting it. Our findings need to be confirmed in prospectively conducted studies with larger sample size.