Is there savings for Pavlovian fear conditioning after neurotoxic basolateral amygdala lesions in rats?
Is there savings for Pavlovian fear conditioning after neurotoxic basolateral amygdala lesions in rats?
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DOI：
10.1006/nlme.2001.4042
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发表时间：
2001-11-01
影响因子：
2.7
通讯作者：
Maren, S
中科院分区：
文献类型：
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作者：
Maren, S
大量证据表明杏仁核在巴甫洛夫恐惧条件反射的获得和表达中起着重要作用。我的实验室最近的报告集中在杏仁核基底外侧复合体神经毒性病变的影响。(BLA)对大鼠条件性冻结行为的影响在这些研究中，我观察到训练后BLA损伤对条件性冻结表达的严重影响，即使是在广泛的术前过度训练之后（25-75次试验）。此外，我没有发现任何证据表明恐惧记忆（即，当我评估这些大鼠相对于接受最低限度训练的BLA大鼠的再摄取率时（1次试验），在这些实验中，使用常规的时间取样程序评估冻结行为，并表示为响应概率。尽管该测量在文献中得到了很好的确立，但可以想象，它对具有BLA病变的大鼠的备用记忆不敏感。为了解决这个问题，我提出了一个更详细的分析冻结行为，量化延迟冻结，冻结回合的数量冻结回合的持续时间，回合长度的概率分布。我还包括来自未经训练（无休克）大鼠的对照数据。与我先前的报告一致，我没有发现任何证据表明，在使用几种冻结行为措施的神经毒性BLA病变大鼠的恐惧记忆的储蓄。这些结果重申了这样的结论，即恐惧记忆，因为它是在冻结行为，需要在BLA的神经元。(C)北京：科学出版社.
Considerable evidence indicates an important role for amygdaloid nuclei in both the acquisition and expression of Pavlovian fear conditioning. Recent reports from my laboratory have focused on the impact of neurotoxic lesions of the basolateral complex of the amygdala. (BLA) on conditional freezing behavior in rats. In these studies, I have observed severe effects of posttraining BLA lesions on the expression of conditional freezing even after extensive presurgical overtraining (25-75 trials). Moreover, I have found no evidence for sparing of fear memory (i.e., savings) in these rats when I assess their rate of reacquisition relative to BLA rats receiving minimal training (1 trial). In these experiments, freezing behavior was assessed using a conventional time-sampling procedure and expressed as a response probability. Although this measure is well established in the literature, it is conceivable that it is not sensitive to spared memory in rats, with BLA lesions. To address, this issue, I present a more detailed analysis of freezing behavior that quantifies latency to freeze, the number of freezing bouts-the duration of freezing bouts, and the probability distribution of bout lengths. I also include control data from untrained (no-shock) rats. Consistent with my earlier reports, I find no evidence of savings of fear memory in rats with neurotoxic BLA lesions using several measures of freezing behavior. These results reiterate the conclusion that fear memory, as it is expressed in freezing behavior, requires neurons in the BLA. (C) 2001 Academic Press.