Effects of stress and aging on ribonucleoprotein assembly and function in the germ line.
Effects of stress and aging on ribonucleoprotein assembly and function in the germ line.
复制标题
压力和衰老对生殖系核糖核蛋白组装和功能的影响。
DOI：
10.1002/wrna.1204
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发表时间：
2014
期刊：
影响因子：
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通讯作者：
Schisa,JenniferA
中科院分区：
文献类型：
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作者：
Schisa,JenniferA
在多种细胞类型中，核糖核蛋白 (RNP) 复合物在调节 RNA 代谢中发挥着关键作用。种系含有在体细胞中也发现的 RNP，例如加工 (P) 小体和应激颗粒，以及种系特有的几种 RNP，包括种系颗粒、nuage、巴尔比亚尼小体、P 颗粒、U 小体和海绵体。最近的进展已经确定了种系 RNP 对营养应激和热休克等环境应激的保守反应。根据细胞学检查，RNP 的大小显着增加；它们的形态和亚细胞定位发生变化，并且它们的组成也发生变化。当压力减弱时，这些动态变化是可逆的，并且类似的变化是由于卵母细胞受精前的衰老或减数分裂停滞而发生的。 RNP 的动力学与微管细胞骨架及其运动蛋白之间存在有趣的相关性，这表明大 RNP 颗粒组装和解离的可能机制。同样，核膜和内质网的协调变化也可能有助于揭示 RNP 动力学的调节机制。根据其组成，RNP 被认为可以调节 mRNA 衰变和/或翻译，并且目前对其中一些作用的初步支持已经到来。最终，为什么 RNP 重塑在各种压力和衰老过程中发生如此大的程度的问题仍有待完全解答，但当前有吸引力的假设是可塑性促进卵母细胞质量的维持。WIREs RNA2014, 5:231–246。 doi: 10.1002/wrna.1204本文分类为：RNA与蛋白质和其他分子的相互作用 > RNA-蛋白质复合物RNA在疾病和发育中的作用 > RNA在疾病中的作用RNA在疾病和发育中的作用 > RNA在发育中的作用
In a variety of cell types, ribonucleoprotein (RNP) complexes play critical roles in regulating RNA metabolism. The germ line contains RNPs found also in somatic cells, such as processing (P) bodies and stress granules, as well as several RNPs unique to the germ line, including germ granules, nuage, Balbiani bodies, P granules, U bodies, and sponge bodies. Recent advances have identified a conserved response of germ line RNPs to environmental stresses such as nutritional stress and heat shock. The RNPs increase significantly in size based on cytology; their morphology and subcellular localization changes, and their composition changes. These dynamic changes are reversible when stresses diminish, and similar changes occur in response to aging or extended meiotic arrest prior to fertilization of oocytes. Intriguing correlations exist between the dynamics of the RNPs and the microtubule cytoskeleton and its motor proteins, suggesting a possible mechanism for the assembly and dissociation of the large RNP granules. Similarly, coordinated changes of the nuclear membrane and endoplasmic reticulum may also help unravel the regulatory mechanisms of RNP dynamics. Based on their composition, the RNPs are thought to regulate mRNA decay and/or translation, and initial support for some of these roles is now at hand. Ultimately, the question of why RNP remodeling occurs to such a large extent during a variety of stresses and aging remains to be fully answered, but a current attractive hypothesis is that the plasticity promotes the maintenance of oocyte quality.WIREs RNA2014, 5:231–246. doi: 10.1002/wrna.1204This article is categorized under:RNA Interactions with Proteins and Other Molecules > RNA–Protein ComplexesRNA in Disease and Development > RNA in DiseaseRNA in Disease and Development > RNA in Development