IMPAIRED DRINKING RESPONSES OF RATS WITH LESIONS OF NUCLEUS MEDIANUS - CIRCADIAN DEPENDENCE
IMPAIRED DRINKING RESPONSES OF RATS WITH LESIONS OF NUCLEUS MEDIANUS - CIRCADIAN DEPENDENCE
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DOI：
10.1152/ajpregu.1985.248.2.r224
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发表时间：
1985-01-01
影响因子：
--
通讯作者：
STRICKER, EM
中科院分区：
文献类型：
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作者：
GARDINER, TW;STRICKER, EM
本文观察了电损毁大鼠腹侧正中核（vNM）后在急性高渗和低血容量状态下的饮水行为。在白天测试时，脑损伤动物对高渗盐水或聚乙二醇溶液系统治疗的饮水反应受损。当同一只动物接受刺激性药物咖啡因预处理或在夜间进行测试时，观察到对两种致渴挑战的正常饮酒反应。vNM的病变可能会产生复杂的改变，在控制饮酒行为，而不是破坏感觉受体。这些病变似乎破坏了对饮酒的昼夜节律影响和饮酒的激活成分，这些成分通常有助于促进行为反应。由此可见，第三脑室吻侧壁的室周组织在饮酒的中枢控制中起重要作用。
The drinking behavior of rats with electrolytic lesions of ventral nucleus medianus (vNM) was examined during acute hyperosmolality and hypovolemia. The brain-damaged animals were impaired in their drinking responses to systemic treatment with hypertonic saline or polyethylene glycol solution when they were tested during the day. Apparently normal drinking responses to both dipsogenic challenges were observed when the same animals were pretreated with the stimulant drug, caffeine, or when they were tested at night. Lesions of vNM may produce complex alterations in the control of drinking behavior rather than the destruction of sensory receptors. The lesions appear to disrupt both circadian influences on drinking and activational components of drinking that normally serve to facilitate the behavioral response. Evidently, periventricular tissue bordering the rostral wall of the 3rd cerebral ventricle plays an important role in the central control of drinking.