Changes in glycogen synthetase and phosphorylase during muscular contraction.
Changes in glycogen synthetase and phosphorylase during muscular contraction.
复制标题
肌肉收缩期间糖原合成酶和磷酸化酶的变化。
DOI：
10.1016/0006-291x(69)90308-8
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发表时间：
1969
影响因子：
3.1
通讯作者：
R. Piras
中科院分区：
文献类型：
--
作者：
R. Staneloni;R. Piras
大鼠骨骼肌强直收缩时，预先刺激其糖原合成酶（I-GS）的葡萄糖-6-P非依赖性比例增加，导致GS从独立型转化为依赖型（D-GS）。这种I到D的转化非常迅速，因为它发生在刺激的前5秒，并且与磷酸化酶a的增加同时发生。这种转换的可能机制进行了研究。在随后的恢复期，糖原磷酸化酶恢复为活性较低的B型，GS恢复为活性较高的I型。这两种酶的活性形式的同时和相反的变化至少通过四个收缩和恢复周期来保持，这表明存在一个系统，该系统似乎与这两种酶相互作用，以在糖原分解或糖原生成过程中实现最大效率。
Tetanic contraction of rat skeletal muscle, previously stimulated to increase its glucose-6-P independent proportion of glycogen synthetase (I-GS), results in the transformation of GS from the independent to the dependent (D-GS) form. This I to D conversion is very rapid, since it takes place during the first 5 sec of stimulation, and occurs simultaneously with an increase of phosphorylase a. Possible mechanisms of this conversion have been investigated. During the ensueing recovery period glycogen phosphorylase is reverted to the less active b form, and GS to the more active I form. The simultaneous and opposite changes in the active forms of both enzymes are mantained, at least, through four cycles of contraction and recovery, suggesting the presence of a system which seems to interlook both enzymes to allow maximal efficiency during glycogenolysis or glycogenesis.