Genomics and genetics in the biology of adaptation to exercise.
Genomics and genetics in the biology of adaptation to exercise.
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DOI：
10.1002/cphy.c100059
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发表时间：
2011-07
影响因子：
5.8
通讯作者：
Timmons JA
中科院分区：
文献类型：
--
作者：
Bouchard C;Rankinen T;Timmons JA
本章致力于研究遗传变异和基因-运动相互作用在运动适应生物学中的作用。来自遗传流行病学研究的证据表明，DNA序列差异有助于人类在体力活动水平、非训练状态下的心肺健康、对急性运动的心血管和代谢反应以及对常规运动的反应方面的差异。方法和技术的进步使得从组织表达谱、基因和等位基因变异的角度对复杂的、多因素的性状的遗传成分进行分子解剖成为可能，例如那些对运动生物学感兴趣的性状。来自动物模型和人体研究的证据也被考虑在内。对候选基因、全基因组连锁结果、全基因组关联发现、表达阵列以及这些方法的组合的数据进行了综述。结合转录和基因组技术已经被证明是更强大的，最近的一种分子预测因子的发展证明了通过运动训练增加最大摄氧量的能力。对于作为一种行为的锻炼和作为一种状态的生理健康，要成为公共卫生政策的主要参与者，将要求理解人类个性的作用和DNA序列差异的影响。同样，在治疗医学中使用运动的进展在很大程度上将取决于我们识别特定运动方案的特定生理特性的有利应答者的能力。
This chapter is devoted to the role of genetic variation and gene-exercise interactions in the biology of adaptation to exercise. There is evidence from genetic epidemiology research that DNA sequence differences contribute to human variation in physical activity level, cardiorespiratory fitness in the untrained state, cardiovascular and metabolic response to acute exercise, and responsiveness to regular exercise. Methodological and technological advances have made it possible to undertake the molecular dissection of the genetic component of complex, multifactorial traits, such as those of interest to exercise biology, in terms of tissue expression profile, genes, and allelic variants. The evidence from animal models and human studies is considered. Data on candidate genes, genome-wide linkage results, genome-wide association findings, expression arrays, and combinations of these approaches are reviewed. Combining transcriptomic and genomic technologies has been shown to be more powerful as evidenced by the development of a recent molecular predictor of the ability to increase VO2max with exercise training. For exercise as a behavior and physiological fitness as a state to be major players in public health policies will require that that the role of human individuality and the influence of DNA sequence differences be understood. Likewise, progress in the use of exercise in therapeutic medicine will depend to a large extent on our ability to identify the favorable responders for given physiological properties to a given exercise regimen.
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影响因子：
9.9
作者：
Andreu, AL;Bruno, C;DiMauro, S
通讯作者：
DiMauro, S
影响因子：
9.8
作者：
Abecasis, GR;Cardon, LR;Cookson, WOC
通讯作者：
Cookson, WOC
影响因子：
6.8
作者：
AKAIKE, H
通讯作者：
AKAIKE, H
DOI：
10.1152/ajpheart.1998.274.3.h860
发表时间：
1998-03-01
影响因子：
4.8
作者：
Annex, BH;Torgan, CE;Kraus, WE
通讯作者：
Kraus, WE
影响因子：
3.3
作者：
Bamman, Marcas M.;Petrella, John K.;Cross, James M.
通讯作者：
Cross, James M.