Social play in juvenile hamsters alters dendritic morphology in the medial prefrontal cortex and attenuates effects of social stress in adulthood.
Social play in juvenile hamsters alters dendritic morphology in the medial prefrontal cortex and attenuates effects of social stress in adulthood.
复制标题
少年仓鼠的社交发挥改变了内侧前额叶皮层中的树突形态，并减轻了成年后社会压力的影响。
DOI：
10.1037/bne0000148
复制
发表时间：
2016-08
影响因子：
1.9
通讯作者：
Cooper MA
中科院分区：
文献类型：
--
作者：
Burleson CA;Pedersen RW;Seddighi S;DeBusk LE;Burghardt GM;Cooper MA
社交游戏是许多物种行为发展的一个基本方面。在大鼠的社会游戏剥夺改变树突状形态的腹内侧前额叶皮层（vmPFC），我们已经表明，这一大脑区域调节反应的社会失败的压力在叙利亚仓鼠。在这项研究中，我们测试了是否在青少年时期的游戏剥夺扰乱了前额叶皮层的树突形态，并加强了社会失败压力的影响。在断奶时，雄性仓鼠要么与同龄人一起群养，要么与它们的母亲成对饲养，它们不与母亲玩耍。在成年期，动物接受急性社会失败压力或无失败对照治疗。然后测试仓鼠在与新入侵者的社交互动测试中的条件性失败反应，并且还测试了对熟悉对手的社交回避。收集大脑进行Golgi-Cox染色并分析边缘下（IL）、边缘前（PL）和眶额皮质（OFC）中的树突形态。与玩耍暴露的动物相比，玩耍剥夺的动物表现出增加的条件性失败反应和升高的对熟悉对手的回避。此外，游戏剥夺的动物表现出增加的总长度和分支点的锥体神经元的顶树突在IL和PL皮质，但不是在OFC。这些研究结果表明，在幼年仓鼠的社会发挥剥夺破坏神经元的发育，在vmPFC和增加的脆弱性，在成年期的社会压力的影响。总的来说，这些结果表明，社交游戏是必要的自然树突修剪过程中，在青春期和促进应对压力的成年。
Social play is a fundamental aspect of behavioral development in many species. Social play deprivation in rats alters dendritic morphology in the ventromedial prefrontal cortex (vmPFC) and we have shown that this brain region regulates responses to social defeat stress in Syrian hamsters. In this study, we tested whether play deprivation during the juvenile period disrupts dendritic morphology in the prefrontal cortex and potentiates the effects of social defeat stress. At weaning, male hamsters were either group-housed with peers or pair-housed with their mother, with whom they do not play. In adulthood, animals received acute social defeat stress or no-defeat control treatment. The hamsters were then tested for a conditioned defeat response in a social interaction test with a novel intruder, and were also tested for social avoidance of a familiar opponent. Brains were collected for Golgi-Cox staining and analysis of dendritic morphology in the infralimbic (IL), prelimbic (PL), and orbitofrontal cortex (OFC). Play-deprived animals showed an increased conditioned defeat response and elevated avoidance of a familiar opponent compared to play-exposed animals. Also, play-deprived animals showed increased total length and branch points in apical dendrites of pyramidal neurons in the IL and PL cortices, but not in the OFC. These findings suggest that social play deprivation in juvenile hamsters disrupts neuronal development in the vmPFC and increases vulnerability to the effects of social stress in adulthood. Overall, these results suggest that social play is necessary for the natural dendritic pruning process during adolescence and promotes coping with stress in adulthood.