Cardiac stem cells: isolation, expansion and experimental use for myocardial regeneration.
Cardiac stem cells: isolation, expansion and experimental use for myocardial regeneration.
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DOI：
10.1038/ncpcardio0738
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发表时间：
2007-02-01
影响因子：
--
通讯作者：
Giacomello, Alessandro
中科院分区：
文献类型：
--
作者：
Barile, Lucio;Chimenti, Isotta;Giacomello, Alessandro
细胞心肌成形术（肌源性细胞移植）作为一种新的方法正在积极探索，以再生受损的心肌。成人心脏含有少量的固有定向心脏干细胞或多能心脏祖细胞，通过其细胞表面表达c-kit（干细胞因子受体）、P-糖蛋白（多药耐药蛋白家族成员）和Sca-1（干细胞抗原1，小鼠造血干细胞标志物）或Sca-1样蛋白来鉴定。心脏干细胞代表了在心脏再生治疗中利用的逻辑来源，因为与其他成体干细胞不同，它们可能被内在地编程以在体外产生心脏组织并在体外增加心脏组织活力。因此，心脏干细胞疗法可能会改变心脏病治疗的基本方法。
Cellular cardiomyoplasty (myogenic cell grafting) is actively being explored as a novel method to regenerate damaged myocardium. The adult human heart contains small populations of indigenous committed cardiac stem cells or multipotent cardiac progenitor cells, identified by their cell-surface expression of c-kit (the receptor for stem cell factor), P-glycoprotein (a member of the multidrug resistance protein family), and Sca-1 (stem cell antigen 1, a mouse hematopoietic stem cell marker) or a Sca-1-like protein. Cardiac stem cells represent a logical source to exploit in cardiac regeneration therapy because, unlike other adult stem cells, they are likely to be intrinsically programmed to generate cardiac tissue in vitro and to increase cardiac tissue viability in vitro. Cardiac stem cell therapy could, therefore, change the fundamental approach to the treatment of heart disease.