Amyloid-like Fibronectin Deposits in the Liver: A Novel Morphologic Finding.
Amyloid-like Fibronectin Deposits in the Liver: A Novel Morphologic Finding.
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DOI：
10.1097/pas.0000000000001585
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发表时间：
2021-02-01
期刊：
影响因子：
--
通讯作者：
Torbenson MS
中科院分区：
文献类型：
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作者：
Yasir S;Rech KL;Chen ZE;Torbenson MS
肝脏中的淀粉样蛋白沉积通过其H&E结果识别，由肝实质的各个隔室中的非细胞嗜酸性粒细胞沉积组成，包括基质、血管和很少的肝细胞。提示淀粉样蛋白的H&E结果随后通过刚果红染色证实，并在临床需要时进行亚型分型。报告了两例无细胞物质的窦状沉积，其在H&E上与淀粉样蛋白非常相似，但刚果红阴性。基于质谱的蛋白质组学分析鉴定该物质为纤连蛋白。在一个病例中，沉积物位于分化良好的肝细胞癌的窦状隙中，在一个病例中位于良性肝脏的窦状隙中。
Amyloid deposits in the liver are recognized by their H&E findings, consisting of acellular eosinophilic deposits in various compartments of the liver parenchyma, including the stroma, vessels, and rarely the hepatocytes. H&E findings that suggest amyloid are then confirmed by Congo red stains and subtyped when clinically needed. Two cases are reported with sinusoidal deposits of acellular material that closely mimicked amyloid on H&E, but were Congo red negative. Mass spectrometry-based proteomic analysis identified the material as fibronectin. In one case, the deposits were located in the sinusoids of a well differentiated hepatocellular carcinoma and in one case in the sinusoids of a benign liver.