Antitumor protective property of an isoprenoid antibiotic, ascofuranone.
Antitumor protective property of an isoprenoid antibiotic, ascofuranone.
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类异戊二烯抗生素壳二呋喃酮的抗肿瘤保护特性。
DOI：
10.7164/antibiotics.35.1547
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发表时间：
1982
期刊：
影响因子：
--
通讯作者：
G. Tamura
中科院分区：
文献类型：
--
作者：
J. Magae;T. Hosokawa;K. Ando;K. Nagai;G. Tamura
抗坏血酸呋喃酮（AF）在肿瘤攻击前7天给药一次，对L-1210白血病具有抗肿瘤保护作用。然而，当宿主小鼠同时用AF处理和肿瘤攻击时，没有引起效果。在肿瘤攻击前第7、5和3天的AF预处理保护宿主免受腹水形式的S-180的影响。移植后24小时，AF每天给药一次，连续5天，也能抑制肿瘤生长，但移植前后联合治疗未见抗肿瘤作用。在埃利希腹水癌中观察到类似的结果。正常小鼠的AF治疗扩大了实体淋巴器官，而不影响体重增加。来自AF处理的小鼠的脾细胞降低了对植物血凝素的促有丝分裂反应，而对刀豆球蛋白A和脂多糖的促有丝分裂反应不受影响。
Ascofuranone (AF) showed an antitumor protective effect on L-1210 leukemia when AF was administered once 7 days before tumor challenge. However, effect was not elicited when host mice were treated with AF simultaneously with tumor challenge. AF pretreatment on day 7, 5 and 3 before tumor challenge protected the host from the ascites form of S-180. AF also retarded tumor growth when administered once daily for 5 consecutive days 24 hours after transplantation, but antitumor effect was not seen with combined treatments before and after the transplantation. Similar results were noted with Ehrlich ascites carcinoma. AF treatment of normal mice enlarged the solid lymphoid organs without affecting body weight gain. The splenocytes derived from AF-treated mice lowered mitogenic response to phytohemagglutinin, while the mitogenic response to concanavalin A and lipopolysaccharide was unaffected.