Homeostasis model assessment is a reliable indicator of insulin resistance during follow-up of patients with type 2 diabetes
Homeostasis model assessment is a reliable indicator of insulin resistance during follow-up of patients with type 2 diabetes
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DOI：
10.2337/diacare.24.2.362
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发表时间：
2001-02-01
期刊：
影响因子：
16.2
通讯作者：
Adachi, Y
中科院分区：
文献类型：
--
作者：
Katsuki, A;Sumida, Y;Adachi, Y
目的-调查的有用性的稳态模型评估作为一个指数的胰岛素抵抗（HOMA-IR）为2型diabetes.RESEARCH设计和方法的患者的临床course评估的HOMA-IR和它与胰岛素抵抗的关系评估的高胰岛素-正葡萄糖钳夹研究（钳夹IR）的有用性在55例日本2型糖尿病患者治疗前后进行了评估。病人们必须节食（类似于1，440- 1，720千卡/天）和运动疗法结果-单变量回归分析显示，在治疗前，HOMA-IR和钳夹IR的对数转换值之间存在显著相关性。（r =-0.613，P < 0.0001），治疗后（r =-0.734，P < 0.0001）。无论是斜坡（-0.71 +/- 0.12 vs. -0.79 +/- 0.09，F = 0.25，P = 0.61），截距也未显示（y轴截距= 1.67 vs. 1.70，x轴截距= 2.36 vs. 2.15，F = 0.02，HOMA-IR与钳夹IR的回归线在治疗前后差异有统计学意义（P = 0.88）。HOMA-IR在治疗期间的下降与钳夹IR的升高有显著相关性（r =-0.617，P < 0.0001）。而且用于2型糖尿病患者治疗期间的随访。
OBJECTIVE- To investigate the usefulness of the homeostasis model assessment as an index of insulin resistance (HOMA-IR) for evaluating the clinical course of patients with type 2 diabetes.RESEARCH DESIGN AND METHODS- The usefulness of HOMA-IR and its relationship with insulin resistance assessed by the hyperinsulinemic-euglycemic clamp study (clamp IR) were evaluated in 55 Japanese patients with type 2 diabetes before and after treatment. The patients were subjected to diet (similar to1,440-1,720 kcal/day) and exercise therapy (walking 10,000 steps daily) for 6 weeks during their hospitalization.RESULTS- Univariate regression analysis disclosed a significant correlation between log transformed HOMA-IR and log-transformed clamp IR before (r = -0.613, P < 0.0001) and after (r = -0.734, P < 0.0001) treatment. Neither the slopes (-0.71 +/- 0.12 vs. -0.79 +/- 0.09, F = 0.25, P = 0.61) nor the intercepts (y-intercept = 1.67 vs. 1.70, x-intercept = 2.36 vs. 2.15, F = 0.02, P = 0.88) of the regression lines between HOMA-IR and clamp IR were significantly different before and after treatment. There was a significant correlation between the decrease in log-transformed HOMA-IR and the increase in clamp IR during treatment (r = -0.617, P < 0.0001).CONCLUSIONS- HOMA-IR may constitute a useful method not only for diagnosing insulin resistance. but also for follow-up during the treatment of patients with type 2 diabetes.