Protein redox by a piezoelectric acousto-nanodevice
Protein redox by a piezoelectric acousto-nanodevice
复制标题
压电声纳米装置的蛋白质氧化还原
DOI：
10.1039/d3nr01523h
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发表时间：
2023
期刊：
影响因子：
6.7
通讯作者：
Song, Seung Hyun
中科院分区：
文献类型：
--
作者：
Selvarajan, Sophia;Shim, Hyunji;Byun, Eunjeong;Kim, Albert;Song, Seung Hyun
蛋白质氧化还原负责许多关键的生物过程；因此，通过外部刺激调节氧化还原蛋白的能力为调节系统提供了一个独特的机会。在这项工作中，我们提出了一种声纳米器件，它能够通过表面工程钛酸钡（BTO）纳米粒子与金半涂层在超声波照射下氧化氧化还原蛋白。使用细胞色素c作为模型蛋白，我们证明了纳米器件介导的蛋白质氧化。通过实验观察，我们发现在超声作用下，由于BTO的交变电极化，电子转移发生在一个方向上。这种独特的单向电子转移是通过调节金表面相对于氧化还原中心的功函数来实现的。新型超声驱动的纳米级蛋白质氧化还原剂可以作为具有高选择性和深层处理位点的生物过程调节剂。
Protein redox is responsible for many crucial biological processes; thus, the ability to modulate the redox proteins through external stimuli presents a unique opportunity to tune the system. In this work, we present an acousto-nanodevice that is capable of oxidizing redox protein under ultrasonic irradiation via surface-engineered barium titanate (BTO) nanoparticles with a gold half-coating. Using cytochrome c as the model protein, we demonstrate nanodevice-mediated protein oxidation. BINased on our experimental observations, we reveal that the electron transfer occurs in one direction due to the alternating electrical polarization of BTO under ultrasound. Such unique unidirectional electron transfer is enabled by modulating the work function of the gold surface with respect to the redox center. The new class of ultrasonically powered nano-sized protein redox agents could be a modulator for biological processes with high selectivity and deeper treatment sites.